Lip impressions: a new method for monitoring morphological changes in orofacial granulomatosis

S Chiandussi, A R Tappuni, T F Watson, A White, M P Escudier, D Sanderson, S J Challacombe

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5 Citations (Scopus)


AIM: To develop and evaluate an objective method for assessing lip size and treatment-related morphological changes in orofacial granulomatosis (OFG) patients. MATERIALS AND METHODS: Patients with swollen lips because of OFG (n = 21) were enrolled. A light-body polyvinylsiloxane material was used to take lip impressions before and after treatment (n = 10), or during treatment (n = 11). Plaster models were cast from the impressions and the lips were measured using callipers. The intra-examiner and inter-examiner reproducibility of the technique were assessed. RESULTS: OFG patients had significantly larger lips than controls (P <0.0001). The coefficient of variation on repeated measurements of the same impression was 1.6% and for duplicate impressions was 2.6%. Significant reduction in lip size was shown in all 10 patients after diet restriction (P <0.002). Seven of 11 patients whose impressions were taken at least 3 months after the initiation of cinnamon- and benzoate-free diet also showed reduction in lip size during follow up (P <0.002). CONCLUSIONS: Serial lip impressions appear to be reliable for routine quantification of morphological changes of the lips in OFG patients. We present a new reproducible and sensitive method for assessing changes in lip size in response to treatment in OFG
Original languageEnglish
Pages (from-to)93 - 98
Number of pages6
JournalOral Diseases
Issue number1
Publication statusPublished - Jan 2007


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