Lip impressions: a new method for monitoring morphological changes in orofacial granulomatosis

TY - JOUR

T1 - Lip impressions: a new method for monitoring morphological changes in orofacial granulomatosis

AU - Chiandussi, S

AU - Tappuni, A R

AU - Watson, T F

AU - White, A

AU - Escudier, M P

AU - Sanderson, D

AU - Challacombe, S J

PY - 2007/1

Y1 - 2007/1

N2 - AIM: To develop and evaluate an objective method for assessing lip size and treatment-related morphological changes in orofacial granulomatosis (OFG) patients. MATERIALS AND METHODS: Patients with swollen lips because of OFG (n = 21) were enrolled. A light-body polyvinylsiloxane material was used to take lip impressions before and after treatment (n = 10), or during treatment (n = 11). Plaster models were cast from the impressions and the lips were measured using callipers. The intra-examiner and inter-examiner reproducibility of the technique were assessed. RESULTS: OFG patients had significantly larger lips than controls (P <0.0001). The coefficient of variation on repeated measurements of the same impression was 1.6% and for duplicate impressions was 2.6%. Significant reduction in lip size was shown in all 10 patients after diet restriction (P <0.002). Seven of 11 patients whose impressions were taken at least 3 months after the initiation of cinnamon- and benzoate-free diet also showed reduction in lip size during follow up (P <0.002). CONCLUSIONS: Serial lip impressions appear to be reliable for routine quantification of morphological changes of the lips in OFG patients. We present a new reproducible and sensitive method for assessing changes in lip size in response to treatment in OFG

AB - AIM: To develop and evaluate an objective method for assessing lip size and treatment-related morphological changes in orofacial granulomatosis (OFG) patients. MATERIALS AND METHODS: Patients with swollen lips because of OFG (n = 21) were enrolled. A light-body polyvinylsiloxane material was used to take lip impressions before and after treatment (n = 10), or during treatment (n = 11). Plaster models were cast from the impressions and the lips were measured using callipers. The intra-examiner and inter-examiner reproducibility of the technique were assessed. RESULTS: OFG patients had significantly larger lips than controls (P <0.0001). The coefficient of variation on repeated measurements of the same impression was 1.6% and for duplicate impressions was 2.6%. Significant reduction in lip size was shown in all 10 patients after diet restriction (P <0.002). Seven of 11 patients whose impressions were taken at least 3 months after the initiation of cinnamon- and benzoate-free diet also showed reduction in lip size during follow up (P <0.002). CONCLUSIONS: Serial lip impressions appear to be reliable for routine quantification of morphological changes of the lips in OFG patients. We present a new reproducible and sensitive method for assessing changes in lip size in response to treatment in OFG

U2 - 10.1111/j.1601-0825.2006.01255.x

DO - 10.1111/j.1601-0825.2006.01255.x

M3 - Article

VL - 13

SP - 93

EP - 98

JO - Oral Diseases

JF - Oral Diseases

IS - 1

ER -