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Lipids in cell biology: how can we understand them better?

Research output: Contribution to journalArticlepeer-review

Eleonora Muro, G. Ekin Atilla-Gokcumen, Ulrike S. Eggert

Original languageEnglish
Pages (from-to)1819-1823
Number of pages5
JournalMol Biol Cell
Volume25
Issue number12
DOIs
Published15 Jun 2014

King's Authors

Abstract

Lipids are a major class of biological molecules and play many key roles in different processes. The diversity of lipids is on the same order of magnitude as that of proteins: cells express tens of thousands of different lipids and hundreds of proteins to regulate their metabolism and transport. Despite their clear importance and essential functions, lipids have not been as well studied as proteins. We discuss here some of the reasons why it has been challenging to study lipids and outline technological developments that are allowing us to begin lifting lipids out of their "Cinderella" status. We focus on recent advances in lipid identification, visualization, and investigation of their biophysics and perturbations and suggest that the field has sufficiently advanced to encourage broader investigation into these intriguing molecules.

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