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Lipopolysaccharide-induced nigral inflammation leads to increased IL-1 beta tissue content and expression of astrocytic glial cell line-derived neurotrophic factor

Research output: Contribution to journalArticle

Mahmoud M. Iravani, Mona Sadeghian, Clement C. M. Leung, Peter Jenner, Sarah Rose

Original languageEnglish
Pages (from-to)138 - 142
Number of pages5
JournalNeuroscience Letters
Volume510
Issue number2
DOIs
Publication statusPublished - 29 Feb 2012

King's Authors

Abstract

Reactive gliosis and inflammatory change is a key component of nigral dopaminergic cell death in Parkinson's disease (PD). Astrocyte derived glial cell line-derived neurotrophic factor (GDNF) promotes the survival and growth of dopaminergic neurones and it protects against or reverses nigral degeneration induced by 6-OHDA and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in rodents and primates. But the effect of increased levels of pro-inflammatory cytokines on the release of GDNF is unknown. This study examined the relationship between release of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) and the expression of GDNF in rats following nigral lipopolysaccharide (LPS) administration. Acute nigral administration of LPS led to marked elevation of IL-1 beta but insignificant INF-cs tissue content and to a prominent expression of GDNF immunoreactivity in astrocytes but not microglia. The results suggest that inflammation is not only involved in neuronal loss but could promote neuronal survival through increased release of GDNF following up-regulation of IL-1 beta. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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