Lithiated porous silicon nanowires stimulate periodontal regeneration

Martti Kaasalainen; Ran Zhang; Priya Vashisth; Anahid Ahmadi Birjandi; Mark S'Ari; Davide Martella; Mark Isaacs; Ermei Makila; Cong Wang; Evelin Moldenhauer; Paul Clarke; Alessandra Pinna; Xuechen Zhang; Salman Ahmad Mustfa; Valeria Caprettini; Alexander Morrell; Eileen Gentleman; Delia S Brauer; Owen Addison; Xuehui Zhang; Mads Bergholt; Khuloud Al-Jamal; Ana Angelova Volponi; Jarno Salonen; Nicole Hondow; Paul Sharpe; Ciro Chiappini

doi:10.1038/s41467-023-44581-5

Lithiated porous silicon nanowires stimulate periodontal regeneration

Martti Kaasalainen, Ran Zhang, Priya Vashisth, Anahid Ahmadi Birjandi, Mark S'Ari, Davide Martella, Mark Isaacs, Ermei Makila, Cong Wang, Evelin Moldenhauer, Paul Clarke, Alessandra Pinna, Xuechen Zhang, Salman Ahmad Mustfa, Valeria Caprettini, Alexander Morrell, Eileen Gentleman, Delia S Brauer, Owen Addison, Xuehui ZhangMads Bergholt, Khuloud Al-Jamal, Ana Angelova Volponi, Jarno Salonen, Nicole Hondow, Paul Sharpe, Ciro Chiappini

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/β-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect.

Original language	English
Article number	487
Journal	Nature Communications
Volume	15
Issue number	1
Early online date	12 Jan 2024
DOIs	https://doi.org/10.1038/s41467-023-44581-5
Publication status	E-pub ahead of print - 12 Jan 2024

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Kaasalainen, M., Zhang, R., Vashisth, P., Ahmadi Birjandi, A., S'Ari, M., Martella, D., Isaacs, M., Makila, E., Wang, C., Moldenhauer, E., Clarke, P., Pinna, A., Zhang, X., Mustfa, S. A., Caprettini, V., Morrell, A., Gentleman, E., Brauer, D. S., Addison, O., ... Chiappini, C. (2024). Lithiated porous silicon nanowires stimulate periodontal regeneration. Nature Communications, 15(1), Article 487. Advance online publication. https://doi.org/10.1038/s41467-023-44581-5

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title = "Lithiated porous silicon nanowires stimulate periodontal regeneration",

abstract = "Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/β-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect.",

author = "Martti Kaasalainen and Ran Zhang and Priya Vashisth and {Ahmadi Birjandi}, Anahid and Mark S'Ari and Davide Martella and Mark Isaacs and Ermei Makila and Cong Wang and Evelin Moldenhauer and Paul Clarke and Alessandra Pinna and Xuechen Zhang and Mustfa, {Salman Ahmad} and Valeria Caprettini and Alexander Morrell and Eileen Gentleman and Brauer, {Delia S} and Owen Addison and Xuehui Zhang and Mads Bergholt and Khuloud Al-Jamal and {Angelova Volponi}, Ana and Jarno Salonen and Nicole Hondow and Paul Sharpe and Ciro Chiappini",

year = "2024",

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doi = "10.1038/s41467-023-44581-5",

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Kaasalainen, M, Zhang, R, Vashisth, P , Ahmadi Birjandi, A, S'Ari, M, Martella, D, Isaacs, M, Makila, E, Wang, C, Moldenhauer, E, Clarke, P, Pinna, A, Zhang, X , Mustfa, SA , Caprettini, V , Morrell, A , Gentleman, E, Brauer, DS, Addison, O, Zhang, X, Bergholt, M , Al-Jamal, K , Angelova Volponi, A, Salonen, J, Hondow, N, Sharpe, P & Chiappini, C 2024, 'Lithiated porous silicon nanowires stimulate periodontal regeneration', Nature Communications, vol. 15, no. 1, 487. https://doi.org/10.1038/s41467-023-44581-5

TY - JOUR

T1 - Lithiated porous silicon nanowires stimulate periodontal regeneration

AU - Kaasalainen, Martti

AU - Zhang, Ran

AU - Vashisth, Priya

AU - Ahmadi Birjandi, Anahid

AU - S'Ari, Mark

AU - Martella, Davide

AU - Isaacs, Mark

AU - Makila, Ermei

AU - Wang, Cong

AU - Moldenhauer, Evelin

AU - Clarke, Paul

AU - Pinna, Alessandra

AU - Zhang, Xuechen

AU - Mustfa, Salman Ahmad

AU - Caprettini, Valeria

AU - Morrell, Alexander

AU - Gentleman, Eileen

AU - Brauer, Delia S

AU - Addison, Owen

AU - Zhang, Xuehui

AU - Bergholt, Mads

AU - Al-Jamal, Khuloud

AU - Angelova Volponi, Ana

AU - Salonen, Jarno

AU - Hondow, Nicole

AU - Sharpe, Paul

AU - Chiappini, Ciro

PY - 2024/1/12

Y1 - 2024/1/12

N2 - Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/β-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect.

AB - Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/β-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect.

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U2 - 10.1038/s41467-023-44581-5

DO - 10.1038/s41467-023-44581-5

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SN - 2041-1723

VL - 15

JO - Nature Communications

JF - Nature Communications

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ER -

Lithiated porous silicon nanowires stimulate periodontal regeneration

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