Liver transplantation for acute-on-chronic liver failure

Florent Artru; Francesca Trovato; Maura Morrison; William Bernal; Mark McPhail

doi:10.1016/S2468-1253(23)00363-1

Liver transplantation for acute-on-chronic liver failure

Florent Artru, Francesca Trovato, Maura Morrison, William Bernal^*, Mark McPhail

^*Corresponding author for this work

Inflammation Biology

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

Acute-on-chronic liver failure (ACLF) occurs in the context of advanced liver disease and is associated with hepatic and extrahepatic organ failure, eventually leading to a major risk of short-term mortality. To date, there are very few effective therapeutic options for ACLF. In many cases, liver transplantation is the only life-saving treatment that has acceptable outcomes in carefully selected recipients. This Review addresses key aspects of the use of liver transplantation for patients with ACLF, providing an in-depth discussion of existing evidence regarding candidate selection, the optimal window for transplantation, potential prioritisation of liver grafts for this indication, and the global management of ACLF to bridge patients to liver transplantation.

Original language	English
Pages (from-to)	564-576
Number of pages	13
Journal	The Lancet Gastroenterology and Hepatology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1016/S2468-1253(23)00363-1
Publication status	Published - Jun 2024

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10.1016/S2468-1253(23)00363-1

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title = "Liver transplantation for acute-on-chronic liver failure",

abstract = "Acute-on-chronic liver failure (ACLF) occurs in the context of advanced liver disease and is associated with hepatic and extrahepatic organ failure, eventually leading to a major risk of short-term mortality. To date, there are very few effective therapeutic options for ACLF. In many cases, liver transplantation is the only life-saving treatment that has acceptable outcomes in carefully selected recipients. This Review addresses key aspects of the use of liver transplantation for patients with ACLF, providing an in-depth discussion of existing evidence regarding candidate selection, the optimal window for transplantation, potential prioritisation of liver grafts for this indication, and the global management of ACLF to bridge patients to liver transplantation.",

author = "Florent Artru and Francesca Trovato and Maura Morrison and William Bernal and Mark McPhail",

note = "Funding Information: The National Institute for Health and Care Research (NIHR) supported MM's salary as an academic foundation trainee. FA was supported by an EASL Joan Rodes Fellowship. MMP is in receipt of a Medical Research Council experimental medicine award, and WB of an NIHR project grant. Publisher Copyright: {\textcopyright} 2024",

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T1 - Liver transplantation for acute-on-chronic liver failure

AU - Artru, Florent

AU - Trovato, Francesca

AU - Morrison, Maura

AU - Bernal, William

AU - McPhail, Mark

N1 - Funding Information: The National Institute for Health and Care Research (NIHR) supported MM's salary as an academic foundation trainee. FA was supported by an EASL Joan Rodes Fellowship. MMP is in receipt of a Medical Research Council experimental medicine award, and WB of an NIHR project grant. Publisher Copyright: © 2024

PY - 2024/6

Y1 - 2024/6

N2 - Acute-on-chronic liver failure (ACLF) occurs in the context of advanced liver disease and is associated with hepatic and extrahepatic organ failure, eventually leading to a major risk of short-term mortality. To date, there are very few effective therapeutic options for ACLF. In many cases, liver transplantation is the only life-saving treatment that has acceptable outcomes in carefully selected recipients. This Review addresses key aspects of the use of liver transplantation for patients with ACLF, providing an in-depth discussion of existing evidence regarding candidate selection, the optimal window for transplantation, potential prioritisation of liver grafts for this indication, and the global management of ACLF to bridge patients to liver transplantation.

AB - Acute-on-chronic liver failure (ACLF) occurs in the context of advanced liver disease and is associated with hepatic and extrahepatic organ failure, eventually leading to a major risk of short-term mortality. To date, there are very few effective therapeutic options for ACLF. In many cases, liver transplantation is the only life-saving treatment that has acceptable outcomes in carefully selected recipients. This Review addresses key aspects of the use of liver transplantation for patients with ACLF, providing an in-depth discussion of existing evidence regarding candidate selection, the optimal window for transplantation, potential prioritisation of liver grafts for this indication, and the global management of ACLF to bridge patients to liver transplantation.

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U2 - 10.1016/S2468-1253(23)00363-1

DO - 10.1016/S2468-1253(23)00363-1

M3 - Review article

C2 - 38309288

AN - SCOPUS:85184076693

SN - 2468-1253

VL - 9

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EP - 576

JO - The Lancet Gastroenterology and Hepatology

JF - The Lancet Gastroenterology and Hepatology

IS - 6

ER -

Liver transplantation for acute-on-chronic liver failure

Abstract

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