Local caspase activity directs engulfment of dendrites during pruning

D W Williams; S Kondo; A Krzyzanowska; Y Hiromi; J W Truman

doi:10.1038/nn1774

Local caspase activity directs engulfment of dendrites during pruning

D W Williams, S Kondo, A Krzyzanowska, Y Hiromi, J W Truman

Developmental Neurobiology

Research output: Contribution to journal › Article › peer-review

296 Citations (Scopus)

Abstract

Pruning is important for sculpting neural circuits, as it removes excessive or inaccurate projections. Here we show that the removal of sensory neuron dendrites during pruning in Drosophila melanogaster is directed by local caspase activity. Suppressing caspase activity prevented dendrite removal, whereas a global activation of caspases within a neuron caused cell death. A new genetically encoded caspase probe revealed that caspase activity is confined to the degenerating dendrites of pruning neurons

Original language	English
Pages (from-to)	1234 - 1236
Number of pages	3
Journal	Nature Neuroscience
Volume	9
Issue number	10
DOIs	https://doi.org/10.1038/nn1774
Publication status	Published - Oct 2006

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title = "Local caspase activity directs engulfment of dendrites during pruning",

abstract = "Pruning is important for sculpting neural circuits, as it removes excessive or inaccurate projections. Here we show that the removal of sensory neuron dendrites during pruning in Drosophila melanogaster is directed by local caspase activity. Suppressing caspase activity prevented dendrite removal, whereas a global activation of caspases within a neuron caused cell death. A new genetically encoded caspase probe revealed that caspase activity is confined to the degenerating dendrites of pruning neurons",

author = "Williams, {D W} and S Kondo and A Krzyzanowska and Y Hiromi and Truman, {J W}",

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AU - Kondo, S

AU - Krzyzanowska, A

AU - Hiromi, Y

AU - Truman, J W

PY - 2006/10

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AB - Pruning is important for sculpting neural circuits, as it removes excessive or inaccurate projections. Here we show that the removal of sensory neuron dendrites during pruning in Drosophila melanogaster is directed by local caspase activity. Suppressing caspase activity prevented dendrite removal, whereas a global activation of caspases within a neuron caused cell death. A new genetically encoded caspase probe revealed that caspase activity is confined to the degenerating dendrites of pruning neurons

U2 - 10.1038/nn1774

DO - 10.1038/nn1774

M3 - Article

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VL - 9

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EP - 1236

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 10

ER -

Local caspase activity directs engulfment of dendrites during pruning

Abstract

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