Localised interventions in cellular processes

Nick Peel; Banafshe Larijani; Peter J. Parker

doi:10.1016/j.bbapap.2013.01.044

Localised interventions in cellular processes

Nick Peel^*, Banafshe Larijani, Peter J. Parker

^*Corresponding author for this work

London Research Institute

Research output: Contribution to journal › Literature review › peer-review

1 Citation (Scopus)

Abstract

The once linear view of cell regulatory processes is now changing as we begin to overlay spatial and temporal characteristics onto signalling pathways and dynamic membranous events. To better understand the properties of these spatially restricted processes we must refine our targeting of these events with acute localised manipulations. We review here the diverse application of a dimerisation system, which exploits immunosuppressor/immunophilin biology to provide a route to drug-inducible subdomain interventions. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012).

Original language	English
Pages (from-to)	1364-1370
Number of pages	7
Journal	BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume	1834
Issue number	7
DOIs	https://doi.org/10.1016/j.bbapap.2013.01.044
Publication status	Published - Jul 2013

Keywords

Spatial signaling
Phospholipid
Rapalogue
Inhibitor
Membrane
Dimerization
PEPTIDYL-PROLYL ISOMERASE
CYTOSOLIC BINDING-PROTEIN
PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE
SACCHAROMYCES-CEREVISIAE
IMMUNOSUPPRESSANT FK506
SIGNAL-TRANSDUCTION
GENE-EXPRESSION
LIVING CELLS
LIGANDS
ACTIVATION

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbapap.2013.01.044

Cite this

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title = "Localised interventions in cellular processes",

abstract = "The once linear view of cell regulatory processes is now changing as we begin to overlay spatial and temporal characteristics onto signalling pathways and dynamic membranous events. To better understand the properties of these spatially restricted processes we must refine our targeting of these events with acute localised manipulations. We review here the diverse application of a dimerisation system, which exploits immunosuppressor/immunophilin biology to provide a route to drug-inducible subdomain interventions. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012).",

keywords = "Spatial signaling, Phospholipid, Rapalogue, Inhibitor, Membrane, Dimerization, PEPTIDYL-PROLYL ISOMERASE, CYTOSOLIC BINDING-PROTEIN, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE, SACCHAROMYCES-CEREVISIAE, IMMUNOSUPPRESSANT FK506, SIGNAL-TRANSDUCTION, GENE-EXPRESSION, LIVING CELLS, LIGANDS, ACTIVATION",

author = "Nick Peel and Banafshe Larijani and Parker, {Peter J.}",

year = "2013",

month = jul,

doi = "10.1016/j.bbapap.2013.01.044",

language = "English",

volume = "1834",

pages = "1364--1370",

journal = "BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS",

issn = "1570-9639",

publisher = "Elsevier",

number = "7",

}

TY - JOUR

T1 - Localised interventions in cellular processes

AU - Peel, Nick

AU - Larijani, Banafshe

AU - Parker, Peter J.

PY - 2013/7

Y1 - 2013/7

N2 - The once linear view of cell regulatory processes is now changing as we begin to overlay spatial and temporal characteristics onto signalling pathways and dynamic membranous events. To better understand the properties of these spatially restricted processes we must refine our targeting of these events with acute localised manipulations. We review here the diverse application of a dimerisation system, which exploits immunosuppressor/immunophilin biology to provide a route to drug-inducible subdomain interventions. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012).

AB - The once linear view of cell regulatory processes is now changing as we begin to overlay spatial and temporal characteristics onto signalling pathways and dynamic membranous events. To better understand the properties of these spatially restricted processes we must refine our targeting of these events with acute localised manipulations. We review here the diverse application of a dimerisation system, which exploits immunosuppressor/immunophilin biology to provide a route to drug-inducible subdomain interventions. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012).

KW - Spatial signaling

KW - Phospholipid

KW - Rapalogue

KW - Inhibitor

KW - Membrane

KW - Dimerization

KW - PEPTIDYL-PROLYL ISOMERASE

KW - CYTOSOLIC BINDING-PROTEIN

KW - PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE

KW - SACCHAROMYCES-CEREVISIAE

KW - IMMUNOSUPPRESSANT FK506

KW - SIGNAL-TRANSDUCTION

KW - GENE-EXPRESSION

KW - LIVING CELLS

KW - LIGANDS

KW - ACTIVATION

U2 - 10.1016/j.bbapap.2013.01.044

DO - 10.1016/j.bbapap.2013.01.044

M3 - Literature review

SN - 1570-9639

VL - 1834

SP - 1364

EP - 1370

JO - BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

JF - BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

IS - 7

ER -

Localised interventions in cellular processes

Abstract

Keywords

UN SDGs

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