Localization of abnormal conduction pathways for tachyarrhythmia treatment using tagged MRI.

GI Sanchez-Ortiz, M Sermesant, KS Rhode, R Chandrashekara, R Razavi, DL Hill, D Rueckert

Research output: Chapter in Book/Report/Conference proceedingConference paper

10 Citations (Scopus)

Abstract

Tachyarrhythmias are pathological fast heart rhythms often caused by abnormally conducting myocardial areas (foci). Treatment by radio-frequency (RF) ablation uses electrode-catheters to monitor and destroy foci. The procedure is normally guided with x-rays (2D), and thus prone to errors in location and excessive radiation exposure. Our main goal is to provide pre- and intra-operative 3D MR guidance in XMR systems by locating the abnormal conduction pathways. We address the inverse electro-mechanical relation by using motion in order to infer electrical propagation. For this purpose we define a probabilistic measure of the onset of regional myocardial activation, derived from 3D motion fields obtained by tracking tagged MR sequences with non-rigid registration. Activation isochrones are then derived to determine activation onset. We also compare regional motion between two different image acquisitions, thus assisting in diagnosing arrhythmia, in follow up of treatment, and in determining whether the ablation was successful. Difference maps of isochrones and other motion descriptors are computed to determine abnormal patterns. Validation was carried out using an electromechanical model of the heart, synthetic data, a cardiac MRI atlas of motion and geometry, MRI data from 6 healthy volunteers (one of them subjected to stress), and an MRI study on a patient with tachyarrhythmia, before and after RF ablation. A pre-operative MRI study on a second patient with tachyarrhythmia was used to test the methodology in a clinical scenario, predicting the abnormally conducting region.
Original languageEnglish
Title of host publicationLECT NOTE COMPUT SCI
PublisherUnknown Publisher
Pages425 - 433
Number of pages9
Volume3749 LNCS
Publication statusPublished - 2005
Event8th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2005) - Palm Springs, United States
Duration: 1 Jan 2005 → …

Conference

Conference8th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2005)
Country/TerritoryUnited States
CityPalm Springs
Period1/01/2005 → …

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