Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI

TY - JOUR

T1 - Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI

AU - Arichi, Tomoki

AU - Whitehead, Kimberley

AU - Barone, Giovanni

AU - Pressler, Ronit

AU - Padormo, Francesco

AU - Edwards, A David

AU - Fabrizi, Lorenzo

PY - 2017/9/12

Y1 - 2017/9/12

N2 - Electroencephalographic recordings from the developing human brain are characterized by spontaneous neuronal bursts, the most common of which is the delta brush. Although similar events in animal models are known to occur in areas of immature cortex and drive their development, their origin in humans has not yet been identified. Here, we use simultaneous EEG-fMRI to localise the source of delta brush events in 10 preterm infants aged 32-36 postmenstrual weeks. The most frequent patterns were left and right posterior-temporal delta brushes which were associated in the left hemisphere with ipsilateral BOLD activation in the insula only; and in the right hemisphere in both the insular and temporal cortices. This direct measure of neural and hemodynamic activity shows that the insula, one of the most densely connected hubs in the developing cortex, is a major source of the transient bursting events that are critical for brain maturation.

AB - Electroencephalographic recordings from the developing human brain are characterized by spontaneous neuronal bursts, the most common of which is the delta brush. Although similar events in animal models are known to occur in areas of immature cortex and drive their development, their origin in humans has not yet been identified. Here, we use simultaneous EEG-fMRI to localise the source of delta brush events in 10 preterm infants aged 32-36 postmenstrual weeks. The most frequent patterns were left and right posterior-temporal delta brushes which were associated in the left hemisphere with ipsilateral BOLD activation in the insula only; and in the right hemisphere in both the insular and temporal cortices. This direct measure of neural and hemodynamic activity shows that the insula, one of the most densely connected hubs in the developing cortex, is a major source of the transient bursting events that are critical for brain maturation.

KW - Journal Article

UR - http://www.scopus.com/inward/record.url?scp=85029787188&partnerID=8YFLogxK

U2 - 10.7554/eLife.27814

DO - 10.7554/eLife.27814

M3 - Article

C2 - 28893378

SN - 2050-084X

VL - 6

SP - 1

EP - 14

JO - eLife

JF - eLife

ER -