Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Lisette Stolk; Guangju Zhai; Joyce B. J. van Meurs; Michael M. P. J. Verbiest; Jenny A. Visser; Karol Estrada; Fernando Rivadeneira; Frances M. Williams; Lynn Cherkas; Panos Deloukas; Nicole Soranzo; Jules J. de Keyzer; Victor J. M. Pop; Paul Lips; Corinne E. I. Lebrun; Yvonne T. van der Schouw; Diederick E. Grobbee; Jacqueline Witteman; Albert Hofman; Huibert A. P. Pols; Joop S. E. Laven; Tim D. Spector; Andre G. Uitterlinden

doi:10.1038/ng.387

Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Lisette Stolk, Guangju Zhai, Joyce B. J. van Meurs, Michael M. P. J. Verbiest, Jenny A. Visser, Karol Estrada, Fernando Rivadeneira, Frances M. Williams, Lynn Cherkas, Panos Deloukas, Nicole Soranzo, Jules J. de Keyzer, Victor J. M. Pop, Paul Lips, Corinne E. I. Lebrun, Yvonne T. van der Schouw, Diederick E. Grobbee, Jacqueline Witteman, Albert Hofman, Huibert A. P. PolsJoop S. E. Laven, Tim D. Spector, Andre G. Uitterlinden

Research output: Contribution to journal › Article › peer-review

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Abstract

We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 x 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 x 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 x 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

Original language	English
Pages (from-to)	645 - 647
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	6
DOIs	https://doi.org/10.1038/ng.387
Publication status	Published - Jun 2009

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Stolk, L., Zhai, G., van Meurs, J. B. J., Verbiest, M. M. P. J., Visser, J. A., Estrada, K., Rivadeneira, F., Williams, F. M., Cherkas, L., Deloukas, P., Soranzo, N., de Keyzer, J. J., Pop, V. J. M., Lips, P., Lebrun, C. E. I., van der Schouw, Y. T., Grobbee, D. E., Witteman, J., Hofman, A., ... Uitterlinden, A. G. (2009). Loci at chromosomes 13, 19 and 20 influence age at natural menopause. Nature Genetics, 41(6), 645 - 647. https://doi.org/10.1038/ng.387

@article{f8e76d4c78314d2d9a88a9d445c2dc40,

title = "Loci at chromosomes 13, 19 and 20 influence age at natural menopause",

abstract = "We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 x 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 x 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 x 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.",

author = "Lisette Stolk and Guangju Zhai and {van Meurs}, {Joyce B. J.} and Verbiest, {Michael M. P. J.} and Visser, {Jenny A.} and Karol Estrada and Fernando Rivadeneira and Williams, {Frances M.} and Lynn Cherkas and Panos Deloukas and Nicole Soranzo and {de Keyzer}, {Jules J.} and Pop, {Victor J. M.} and Paul Lips and Lebrun, {Corinne E. I.} and {van der Schouw}, {Yvonne T.} and Grobbee, {Diederick E.} and Jacqueline Witteman and Albert Hofman and Pols, {Huibert A. P.} and Laven, {Joop S. E.} and Spector, {Tim D.} and Uitterlinden, {Andre G.}",

year = "2009",

month = jun,

doi = "10.1038/ng.387",

language = "English",

volume = "41",

pages = "645 -- 647",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Research",

number = "6",

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Stolk, L, Zhai, G, van Meurs, JBJ, Verbiest, MMPJ, Visser, JA, Estrada, K, Rivadeneira, F, Williams, FM , Cherkas, L, Deloukas, P, Soranzo, N, de Keyzer, JJ, Pop, VJM, Lips, P, Lebrun, CEI, van der Schouw, YT, Grobbee, DE, Witteman, J, Hofman, A, Pols, HAP, Laven, JSE, Spector, TD & Uitterlinden, AG 2009, 'Loci at chromosomes 13, 19 and 20 influence age at natural menopause', Nature Genetics, vol. 41, no. 6, pp. 645 - 647. https://doi.org/10.1038/ng.387

TY - JOUR

T1 - Loci at chromosomes 13, 19 and 20 influence age at natural menopause

AU - Stolk, Lisette

AU - Zhai, Guangju

AU - van Meurs, Joyce B. J.

AU - Verbiest, Michael M. P. J.

AU - Visser, Jenny A.

AU - Estrada, Karol

AU - Rivadeneira, Fernando

AU - Williams, Frances M.

AU - Cherkas, Lynn

AU - Deloukas, Panos

AU - Soranzo, Nicole

AU - de Keyzer, Jules J.

AU - Pop, Victor J. M.

AU - Lips, Paul

AU - Lebrun, Corinne E. I.

AU - van der Schouw, Yvonne T.

AU - Grobbee, Diederick E.

AU - Witteman, Jacqueline

AU - Hofman, Albert

AU - Pols, Huibert A. P.

AU - Laven, Joop S. E.

AU - Spector, Tim D.

AU - Uitterlinden, Andre G.

PY - 2009/6

Y1 - 2009/6

N2 - We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 x 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 x 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 x 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

AB - We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 x 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 x 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 x 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

U2 - 10.1038/ng.387

DO - 10.1038/ng.387

M3 - Article

SN - 1546-1718

VL - 41

SP - 645

EP - 647

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Abstract

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