Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Lisette Stolk, Guangju Zhai, Joyce B. J. van Meurs, Michael M. P. J. Verbiest, Jenny A. Visser, Karol Estrada, Fernando Rivadeneira, Frances M. Williams, Lynn Cherkas, Panos Deloukas, Nicole Soranzo, Jules J. de Keyzer, Victor J. M. Pop, Paul Lips, Corinne E. I. Lebrun, Yvonne T. van der Schouw, Diederick E. Grobbee, Jacqueline Witteman, Albert Hofman, Huibert A. P. PolsJoop S. E. Laven, Tim D. Spector, Andre G. Uitterlinden

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)

Abstract

We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 x 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 x 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 x 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.
Original languageEnglish
Pages (from-to)645 - 647
Number of pages3
JournalNature Genetics
Volume41
Issue number6
DOIs
Publication statusPublished - Jun 2009

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