Long-acting paliperidone palmitate: interim results of an observational study of its effect on hospitalization

David Taylor*, Olubanke Olofinjana

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Paliperidone palmitate (PP) is a recently introduced long-acting atypical, or second-generation, antipsychotic. Published data on PP are currently limited to controlled trials and case reports. In this observational study, we followed up 200 consecutive patients prescribed PP in normal practice. After 1 year, 65% of patients were still receiving PP. The number of admissions to hospital in the year following PP initiation was 0.49/patient compared with 0.69/patient/year, 3 years before initiation (P = 0.0001). The mean number of bed days fell from 38.78 to 23.09/patient/year over the corresponding period (P = 0.0001). The median number of bed days 3 years before PP initiation was 21.50/year and in the year following PP initiation, it was 0. Outcomes were numerically but not statistically better in those continuing PP than in those who ceased PP within a year of initiation. PP was effective and well-tolerated and, given its positive effect on hospital bed days, broadly cost-effective.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalInternational Clinical Psychopharmacology
Volume29
Issue number4
DOIs
Publication statusPublished - Jul 2014

Keywords

  • antipsychotic
  • long-acting injection
  • paliperidone
  • schizophrenia
  • DRUG-MONITORING SERVICE
  • RESOURCE UTILIZATION
  • MIRROR-IMAGE
  • RISPERIDONE
  • INJECTION
  • SCHIZOPHRENIA
  • CARE
  • 9-HYDROXYRISPERIDONE
  • ANTIPSYCHOTICS

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