TY - JOUR
T1 - Long COVID and post-infective fatigue syndrome
T2 - A review
AU - Sandler, Carolina X
AU - Wyller, Vegard Bruun
AU - Moss-Morris, Rona
AU - Buchwald, Dedra
AU - Crawley, Esther
AU - Hautvast, Jeannine L.A.
AU - Katz, Ben Z
AU - Knoop, Hans
AU - Little, Paul
AU - Taylor, Renee
AU - Wensaas, Knut-Arne
AU - Lloyd, Andrew
N1 - Funding Information:
A. R. L. is supported by a National Health and Medical Research Council Practitioner Fellowship (Grant 1041897). C. X. S. is supported by the Mason Foundation National Medical Program. R. M.-M. is partly funded by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London.
Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed "long-COVID"), with up to 46% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13% to 33% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10%-35% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.
AB - Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed "long-COVID"), with up to 46% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13% to 33% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10%-35% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.
KW - Long COVID
KW - post-infective fatigue syndrome
KW - Fatigue
UR - http://www.scopus.com/inward/record.url?scp=85116052715&partnerID=8YFLogxK
U2 - 10.1093/ofid/ofab440
DO - 10.1093/ofid/ofab440
M3 - Article
SN - 2328-8957
VL - 8
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
IS - 10
M1 - ofab440
ER -
