Long-term effects of tibolone on mammographic density

D Bruce; J Robinson; S McWilliams; M Reddy; I Fentiman; J Rymer

doi:10.1016/j.fertnstert.2004.03.063

Long-term effects of tibolone on mammographic density

D Bruce, J Robinson, S McWilliams, M Reddy, I Fentiman, J Rymer

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Objective: To investigate the long-term effect of tibolone on mammographic density. Design: Open-label, nonrandomized study. Setting: Academic research environment. Patient(s): Postmenopausal women. Intervention(s): Tibolone was administered orally, mammograrns were performed annually. Main Outcome Measure(s): Mammographic density according to the Wolfe classification, performed by two independent radiologists, both of whom were blinded to treatment group. Result(s): No statistically significant differences were found between the two groups in baseline demographic data. There were no statistically significant differences in mammographic density between the control and active groups at baseline or at 10 years. Conclusion(s): This pilot study shows that tibolone does not adversely alter the mammographic density of the breasts over 10 years of treatment. (C) 2004 by American Society for Reproductive Medicine.

Original language	English
Pages (from-to)	1343 - 1347
Number of pages	5
Journal	Fertility and Sterility
Volume	82
Issue number	5
DOIs	https://doi.org/10.1016/j.fertnstert.2004.03.063
Publication status	Published - Nov 2004

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10.1016/j.fertnstert.2004.03.063

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title = "Long-term effects of tibolone on mammographic density",

abstract = "Objective: To investigate the long-term effect of tibolone on mammographic density. Design: Open-label, nonrandomized study. Setting: Academic research environment. Patient(s): Postmenopausal women. Intervention(s): Tibolone was administered orally, mammograrns were performed annually. Main Outcome Measure(s): Mammographic density according to the Wolfe classification, performed by two independent radiologists, both of whom were blinded to treatment group. Result(s): No statistically significant differences were found between the two groups in baseline demographic data. There were no statistically significant differences in mammographic density between the control and active groups at baseline or at 10 years. Conclusion(s): This pilot study shows that tibolone does not adversely alter the mammographic density of the breasts over 10 years of treatment. (C) 2004 by American Society for Reproductive Medicine.",

author = "D Bruce and J Robinson and S McWilliams and M Reddy and I Fentiman and J Rymer",

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AU - Bruce, D

AU - Robinson, J

AU - McWilliams, S

AU - Reddy, M

AU - Fentiman, I

AU - Rymer, J

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Long-term effects of tibolone on mammographic density

Abstract

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