Abstract
Background and Aims: To investigate the changes in a range of outcomes up to 10 years after stroke in young ischemic patients aged 15-54 years as compared to those over 55 years.
Method: Data from the South London Stroke Register (SLSR) were studied. Ischaemic stroke subtypes were classified based on Trial of Org 10172 in Acute Stroke Treatment (TOAST). Outcomes included death, disability, activity, depression, anxiety and quality of life. T-test, Chi-square test, and Fisher exact test were performed when appropriate. A best-fit curve for each long-time outcome up to 10 years was produced using the locally-weighted scatter plot smoothing (LOWESS) regression method.
Results: 2,864 patients experienced a first-ever ischaemic stroke between 1999 and 2016, of which 421 (14.7%) were young patients aged 15-54 years as compared to 2,443 (85.3%) patients aged 55 years and over. Young patients were more likely to be male, black, smokers, drinkers, and have lower prevalence of most vascular risk factors, as compared to older patients. Young large-artery atherosclerosis (LAA) and cardioembolism (CE) patients with poor functional outcomes were more likely to be male, to have hypertension. Generally, young patients had better functional outcomes but worse mental consequences than older patients. Among young patients, those with small-vessel occlusion (SVO) had a better functional outcome and a worse mental consequence than those with LAA and CE.
Conclusion: Long-term outcomes appear to be influenced by aetiological stroke subtypes and onset age. Long-term treatment strategies tailored to the needs of different subtypes are needed for young ischemic stroke patients.
Method: Data from the South London Stroke Register (SLSR) were studied. Ischaemic stroke subtypes were classified based on Trial of Org 10172 in Acute Stroke Treatment (TOAST). Outcomes included death, disability, activity, depression, anxiety and quality of life. T-test, Chi-square test, and Fisher exact test were performed when appropriate. A best-fit curve for each long-time outcome up to 10 years was produced using the locally-weighted scatter plot smoothing (LOWESS) regression method.
Results: 2,864 patients experienced a first-ever ischaemic stroke between 1999 and 2016, of which 421 (14.7%) were young patients aged 15-54 years as compared to 2,443 (85.3%) patients aged 55 years and over. Young patients were more likely to be male, black, smokers, drinkers, and have lower prevalence of most vascular risk factors, as compared to older patients. Young large-artery atherosclerosis (LAA) and cardioembolism (CE) patients with poor functional outcomes were more likely to be male, to have hypertension. Generally, young patients had better functional outcomes but worse mental consequences than older patients. Among young patients, those with small-vessel occlusion (SVO) had a better functional outcome and a worse mental consequence than those with LAA and CE.
Conclusion: Long-term outcomes appear to be influenced by aetiological stroke subtypes and onset age. Long-term treatment strategies tailored to the needs of different subtypes are needed for young ischemic stroke patients.
| Original language | English |
|---|---|
| Article number | AS16-042 |
| Pages (from-to) | 349-349 |
| Number of pages | 1 |
| Journal | European Stroke Journal |
| Volume | 3 |
| Issue number | 1_suppl |
| DOIs | |
| Publication status | Published - 16 May 2018 |
| Event | European Stroke Organisation Conference 2018, Gothenburg, May 2018 - Gothenburg, Sweden Duration: 16 May 2018 → 18 May 2018 |