Abstract
Background and aims: We aimed to estimate time trends in incidence, prior risk factors and premorbid medications and to investigate any demographic difference.
Methods: Population-based longitudinal data from South London Stroke Register(SLSR) from 1995 to 2018 was studied. Haemorrhagic stroke(HS) was classified as intracerebral haemorrhage(ICH) and subarachnoid haemorrhage(SAH). Incidence was calculated as new cases of HS every year divided by the estimated population in the study area. Incidence rates were stratified into age-, sex- and ethnic-groups for the 24-year period and directly standardised using 2011 England and Wales population. We analysed the trend using Cochran-Armitage tests and Poisson regression models.
Results: A total of 1119 with first HS was registered, including 811 ICH and 308 SAH patients. Between 1992-2000 and 2013-2018, the standardised HS incidence decreased by 53% from 41.66 to 19.38/100,000/year (incidence rate ratio[IRR]: 0.47, 95%CI: 0.41-0.53). Declines were observed in ICH(IR:41.66-19.38, p=55 years old) individuals, and white and black ethnic groups, though not significantly in young ICH patients(7.20-4.39, p=0.30), female(10.81-5.23, p=0.10) and black(10.28-5.20, p=0.12) SAH patients. Cholesterol lowering drugs was 8 times increasingly used(OR:8.65, 95%CI: 3.97-18.83, p
Conclusions: The incidence rate of HS has been declining since 1995 in all stratified groups, but trend in the most recent 12 years were into a lesser extent. The reported changes in medication use and risk factor are unlikely to fully explain the reduction.
Methods: Population-based longitudinal data from South London Stroke Register(SLSR) from 1995 to 2018 was studied. Haemorrhagic stroke(HS) was classified as intracerebral haemorrhage(ICH) and subarachnoid haemorrhage(SAH). Incidence was calculated as new cases of HS every year divided by the estimated population in the study area. Incidence rates were stratified into age-, sex- and ethnic-groups for the 24-year period and directly standardised using 2011 England and Wales population. We analysed the trend using Cochran-Armitage tests and Poisson regression models.
Results: A total of 1119 with first HS was registered, including 811 ICH and 308 SAH patients. Between 1992-2000 and 2013-2018, the standardised HS incidence decreased by 53% from 41.66 to 19.38/100,000/year (incidence rate ratio[IRR]: 0.47, 95%CI: 0.41-0.53). Declines were observed in ICH(IR:41.66-19.38, p=55 years old) individuals, and white and black ethnic groups, though not significantly in young ICH patients(7.20-4.39, p=0.30), female(10.81-5.23, p=0.10) and black(10.28-5.20, p=0.12) SAH patients. Cholesterol lowering drugs was 8 times increasingly used(OR:8.65, 95%CI: 3.97-18.83, p
Conclusions: The incidence rate of HS has been declining since 1995 in all stratified groups, but trend in the most recent 12 years were into a lesser extent. The reported changes in medication use and risk factor are unlikely to fully explain the reduction.
| Original language | English |
|---|---|
| Article number | 1656 |
| Pages (from-to) | 144-144 |
| Journal | European Stroke Journal |
| Volume | 8 |
| Issue number | 2_suppl |
| DOIs | |
| Publication status | Published - 24 May 2023 |
