TY - JOUR
T1 - Longitudinal associations between greenspace exposure, structural brain development, and mental health and academic performance during early adolescence
AU - Li, Qingyang
AU - Whittle, Sarah
AU - Rakesh, Divyangana
N1 - Publisher Copyright:
© 2025 Society of Biological Psychiatry
PY - 2025/4/11
Y1 - 2025/4/11
N2 - Background: Greenspace exposure is associated with positive mental health and academic outcomes. In this preregistered longitudinal study, we examined whether the influence of greenspace exposure on structural brain development partially explains these associations. Methods: We analyzed data from the ABCD (Adolescent Brain Cognitive Development) Study (n = 7102) to test the relationship between greenspace exposure at ages 9 to 10 years and brain structure 2 years later, as well as changes over time. We also tested whether brain structural development statistically mediated the associations of greenspace exposure with mental health and academic performance. Results: Higher greenspace exposure was associated with greater total surface area (SA) and cortical volume (CV); greater cortical thickness in temporal regions and the insula; lower thickness in the caudal middle frontal and superior frontal gyri; greater SA across several regions; and greater volume of the caudate nucleus, putamen, and nucleus accumbens. In analyses studying changes in brain structure over time, higher greenspace exposure was associated with greater growth of total SA, lower average thickness reduction, and reduced total CV growth as well as changes at the regional level. We also found significant indirect effects of the association of greenspace exposure with academic performance and mental health through both total and regional cortical structure. Conclusions: Greenspace exposure is linked to structural neurodevelopment, which in turn is associated with better mental health and academic achievement. Our findings underscore the importance of greenspace in supporting brain development and positive outcomes in children and adolescents.
AB - Background: Greenspace exposure is associated with positive mental health and academic outcomes. In this preregistered longitudinal study, we examined whether the influence of greenspace exposure on structural brain development partially explains these associations. Methods: We analyzed data from the ABCD (Adolescent Brain Cognitive Development) Study (n = 7102) to test the relationship between greenspace exposure at ages 9 to 10 years and brain structure 2 years later, as well as changes over time. We also tested whether brain structural development statistically mediated the associations of greenspace exposure with mental health and academic performance. Results: Higher greenspace exposure was associated with greater total surface area (SA) and cortical volume (CV); greater cortical thickness in temporal regions and the insula; lower thickness in the caudal middle frontal and superior frontal gyri; greater SA across several regions; and greater volume of the caudate nucleus, putamen, and nucleus accumbens. In analyses studying changes in brain structure over time, higher greenspace exposure was associated with greater growth of total SA, lower average thickness reduction, and reduced total CV growth as well as changes at the regional level. We also found significant indirect effects of the association of greenspace exposure with academic performance and mental health through both total and regional cortical structure. Conclusions: Greenspace exposure is linked to structural neurodevelopment, which in turn is associated with better mental health and academic achievement. Our findings underscore the importance of greenspace in supporting brain development and positive outcomes in children and adolescents.
UR - http://www.scopus.com/inward/record.url?scp=105008897277&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2025.03.026
DO - 10.1016/j.biopsych.2025.03.026
M3 - Article
C2 - 40222467
SN - 0006-3223
JO - Biological psychiatry
JF - Biological psychiatry
ER -
