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Longitudinal segmentation of age-related white matter hyperintensities

Research output: Contribution to journalArticle

Carole H. Sudre, M. Jorge Cardoso, Sebastien Ourselin, Alzheimer's Disease Neuroimaging Initiative

Original languageEnglish
Pages (from-to)50-64
Number of pages15
JournalMedical Image Analysis
Early online date24 Feb 2017
Publication statusPublished - 1 May 2017

King's Authors


Although white matter hyperintensities evolve in the course of ageing, few solutions exist to consider the lesion segmentation problem longitudinally. Based on an existing automatic lesion segmentation algorithm, a longitudinal extension is proposed. For evaluation purposes, a longitudinal lesion simulator is created allowing for the comparison between the longitudinal and the cross-sectional version in various situations of lesion load progression. Finally, applied to clinical data, the proposed framework demonstrates an increased robustness compared to available cross-sectional methods and findings are aligned with previously reported clinical patterns.

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