Looking for Sunshine: Genetic Predisposition to Sun-Seeking in 265,000 Individuals of European Ancestry

Marianna Sanna; Xin Li; Alessia Visconti; Maxim B Freidin; Chiara Sacco; Simone Ribero; Pirro Hysi; Veronique Bataille; Jiali Han; Mario Falchi

doi:10.1016/j.jid.2020.08.014

Looking for Sunshine: Genetic Predisposition to Sun-Seeking in 265,000 Individuals of European Ancestry

Marianna Sanna, Xin Li, Alessia Visconti, Maxim B Freidin, Chiara Sacco, Simone Ribero, Pirro Hysi, Veronique Bataille, Jiali Han, Mario Falchi

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London SE1 7EH, UK. Electronic address: [email protected].
Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University, Indianapolis 46202, IN, USA.
University of Bologna
University of Turin
Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK; Dermatology Department West Herts NHS Trust, Herts, UK.
Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK. Electronic address: [email protected].

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Abstract

Despite growing public awareness of the adverse consequences of excessive sun exposure, modifying sun-seeking behavior is challenging because it appears to be driven by addictive mechanisms. This can have effects on health because sun exposure, although beneficial, when prolonged and repeated shows a causal relationship with skin cancer risk. Using data from 2,500 United Kingdom twins, we observed sun seeking to be significantly heritable (h2 ≥ 58%). In a GWAS meta-analysis of sun-seeking behavior in 261,915 subjects of European ancestry, we identified five GWAS-significant loci previously associated with addiction, behavioral and personality traits, cognitive function, and educational attainment and enriched for CNS gene expression: MIR2113 (P = 2.08 × 10 ⁻¹¹), FAM76B/MTMR2/CEP57 (P = 3.70 × 10 ⁻⁹), CADM2 (P = 9.36 × 10 ⁻⁹), TMEM182 (P = 1.64 × 10 ⁻⁸), and PLCL1/LINC01923/SATB2 (P = 3.93 × 10 ⁻⁸). These findings imply that the behavior concerning UV exposure is complicated by a genetic predisposition shared with neuropsychological traits. This should be taken into consideration when designing awareness campaigns and may help improve people's attitudes toward sun exposure.

Original language	English
Journal	Journal of Investigative Dermatology
DOIs	https://doi.org/10.1016/j.jid.2020.08.014
Publication status	E-pub ahead of print - 10 Sept 2020

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title = "Looking for Sunshine: Genetic Predisposition to Sun-Seeking in 265,000 Individuals of European Ancestry",

abstract = "Despite growing public awareness of the adverse consequences of excessive sun exposure, modifying sun-seeking behavior is challenging because it appears to be driven by addictive mechanisms. This can have effects on health because sun exposure, although beneficial, when prolonged and repeated shows a causal relationship with skin cancer risk. Using data from 2,500 United Kingdom twins, we observed sun seeking to be significantly heritable (h2 ≥ 58%). In a GWAS meta-analysis of sun-seeking behavior in 261,915 subjects of European ancestry, we identified five GWAS-significant loci previously associated with addiction, behavioral and personality traits, cognitive function, and educational attainment and enriched for CNS gene expression: MIR2113 (P = 2.08 × 10 −11), FAM76B/MTMR2/CEP57 (P = 3.70 × 10 −9), CADM2 (P = 9.36 × 10 −9), TMEM182 (P = 1.64 × 10 −8), and PLCL1/LINC01923/SATB2 (P = 3.93 × 10 −8). These findings imply that the behavior concerning UV exposure is complicated by a genetic predisposition shared with neuropsychological traits. This should be taken into consideration when designing awareness campaigns and may help improve people's attitudes toward sun exposure. ",

author = "Marianna Sanna and Xin Li and Alessia Visconti and Freidin, {Maxim B} and Chiara Sacco and Simone Ribero and Pirro Hysi and Veronique Bataille and Jiali Han and Mario Falchi",

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AU - Visconti, Alessia

AU - Freidin, Maxim B

AU - Sacco, Chiara

AU - Ribero, Simone

AU - Hysi, Pirro

AU - Bataille, Veronique

AU - Han, Jiali

AU - Falchi, Mario

PY - 2020/9/10

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N2 - Despite growing public awareness of the adverse consequences of excessive sun exposure, modifying sun-seeking behavior is challenging because it appears to be driven by addictive mechanisms. This can have effects on health because sun exposure, although beneficial, when prolonged and repeated shows a causal relationship with skin cancer risk. Using data from 2,500 United Kingdom twins, we observed sun seeking to be significantly heritable (h2 ≥ 58%). In a GWAS meta-analysis of sun-seeking behavior in 261,915 subjects of European ancestry, we identified five GWAS-significant loci previously associated with addiction, behavioral and personality traits, cognitive function, and educational attainment and enriched for CNS gene expression: MIR2113 (P = 2.08 × 10 −11), FAM76B/MTMR2/CEP57 (P = 3.70 × 10 −9), CADM2 (P = 9.36 × 10 −9), TMEM182 (P = 1.64 × 10 −8), and PLCL1/LINC01923/SATB2 (P = 3.93 × 10 −8). These findings imply that the behavior concerning UV exposure is complicated by a genetic predisposition shared with neuropsychological traits. This should be taken into consideration when designing awareness campaigns and may help improve people's attitudes toward sun exposure.

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Looking for Sunshine: Genetic Predisposition to Sun-Seeking in 265,000 Individuals of European Ancestry

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