Low baseline startle and deficient affective startle modulation in remitted bipolar disorder patients and their unaffected siblings

Stella G. Giakoumaki; Panos Bitsios; Sofia Frangou; Panos Roussos; Ingrid Aasen; Adrian Galea; Veena Kumari

doi:10.1111/j.1469-8986.2010.00977.x

Low baseline startle and deficient affective startle modulation in remitted bipolar disorder patients and their unaffected siblings

Stella G. Giakoumaki, Panos Bitsios, Sofia Frangou, Panos Roussos, Ingrid Aasen, Adrian Galea, Veena Kumari

Research output: Contribution to journal › Literature review › peer-review

24 Citations (Scopus)

Abstract

We examined whether startle abnormalities are present in bipolar disorder (BD) patients and their unaffected siblings. Twenty-one remitted patients with BD, 19 unaffected siblings, and 42 controls were presented with 18 pleasant, 18 unpleasant, and 18 neutral pictures. Acoustic probes (104 dB) were presented during 12 of 18 pictures in each affective category at 300, 3000, and 4500 ms after picture onset, so that there were 4 pictures per valence per probe onset type. Baseline startle was assessed during blank screens and was found reduced in patients and sibling groups. We found startle inhibition with the 300 probes and a linear increase in amplitude with valence with the late probes in controls; these effects were absent in patients and their siblings. Low startle and blunted startle reactivity may represent trait deficits in remitted BD patients and their relatives, possibly associated with attentional deficits and adaptive down-regulation of emotion.

Original language	English
Pages (from-to)	659 - 668
Number of pages	10
Journal	Psychophysiology
Volume	47
Issue number	4
DOIs	https://doi.org/10.1111/j.1469-8986.2010.00977.x
Publication status	Published - Jul 2010

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title = "Low baseline startle and deficient affective startle modulation in remitted bipolar disorder patients and their unaffected siblings",

abstract = "We examined whether startle abnormalities are present in bipolar disorder (BD) patients and their unaffected siblings. Twenty-one remitted patients with BD, 19 unaffected siblings, and 42 controls were presented with 18 pleasant, 18 unpleasant, and 18 neutral pictures. Acoustic probes (104 dB) were presented during 12 of 18 pictures in each affective category at 300, 3000, and 4500 ms after picture onset, so that there were 4 pictures per valence per probe onset type. Baseline startle was assessed during blank screens and was found reduced in patients and sibling groups. We found startle inhibition with the 300 probes and a linear increase in amplitude with valence with the late probes in controls; these effects were absent in patients and their siblings. Low startle and blunted startle reactivity may represent trait deficits in remitted BD patients and their relatives, possibly associated with attentional deficits and adaptive down-regulation of emotion.",

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T1 - Low baseline startle and deficient affective startle modulation in remitted bipolar disorder patients and their unaffected siblings

AU - Giakoumaki, Stella G.

AU - Bitsios, Panos

AU - Frangou, Sofia

AU - Roussos, Panos

AU - Aasen, Ingrid

AU - Galea, Adrian

AU - Kumari, Veena

PY - 2010/7

Y1 - 2010/7

N2 - We examined whether startle abnormalities are present in bipolar disorder (BD) patients and their unaffected siblings. Twenty-one remitted patients with BD, 19 unaffected siblings, and 42 controls were presented with 18 pleasant, 18 unpleasant, and 18 neutral pictures. Acoustic probes (104 dB) were presented during 12 of 18 pictures in each affective category at 300, 3000, and 4500 ms after picture onset, so that there were 4 pictures per valence per probe onset type. Baseline startle was assessed during blank screens and was found reduced in patients and sibling groups. We found startle inhibition with the 300 probes and a linear increase in amplitude with valence with the late probes in controls; these effects were absent in patients and their siblings. Low startle and blunted startle reactivity may represent trait deficits in remitted BD patients and their relatives, possibly associated with attentional deficits and adaptive down-regulation of emotion.

AB - We examined whether startle abnormalities are present in bipolar disorder (BD) patients and their unaffected siblings. Twenty-one remitted patients with BD, 19 unaffected siblings, and 42 controls were presented with 18 pleasant, 18 unpleasant, and 18 neutral pictures. Acoustic probes (104 dB) were presented during 12 of 18 pictures in each affective category at 300, 3000, and 4500 ms after picture onset, so that there were 4 pictures per valence per probe onset type. Baseline startle was assessed during blank screens and was found reduced in patients and sibling groups. We found startle inhibition with the 300 probes and a linear increase in amplitude with valence with the late probes in controls; these effects were absent in patients and their siblings. Low startle and blunted startle reactivity may represent trait deficits in remitted BD patients and their relatives, possibly associated with attentional deficits and adaptive down-regulation of emotion.

U2 - 10.1111/j.1469-8986.2010.00977.x

DO - 10.1111/j.1469-8986.2010.00977.x

M3 - Literature review

VL - 47

SP - 659

EP - 668

JO - Psychophysiology

JF - Psychophysiology

IS - 4

ER -

Low baseline startle and deficient affective startle modulation in remitted bipolar disorder patients and their unaffected siblings

Abstract

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