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Low duplicability and network fragility of cancer genes

Research output: Contribution to journalArticle

Davide Rambaldi, Federico M. Giorgi, Fabrizio Capuani, Andrea Ciliberto, Francesca D. Ciccarelli

Original languageEnglish
Article numberN/A
Pages (from-to)427-430
Number of pages4
JournalTrends in Genetics
Issue number9
Publication statusPublished - Sep 2008

King's Authors


We identified genomic and network properties of ∼600 genes mutated in different cancer types. These genes tend not to duplicate but, unlike most human singletons, they encode central hubs of highly interconnected modules within the protein–protein interaction network (PIN). We find that cancer genes are fragile components of the human gene repertoire, sensitive to dosage modification. Furthermore, other nodes of the human PIN with similar properties are rare and probably enriched in candidate cancer genes.

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