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Low duplicability and network fragility of cancer genes

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Low duplicability and network fragility of cancer genes. / Rambaldi, Davide; Giorgi, Federico M.; Capuani, Fabrizio; Ciliberto, Andrea; Ciccarelli, Francesca D.

In: Trends in Genetics, Vol. 24, No. 9, N/A, 09.2008, p. 427-430.

Research output: Contribution to journalArticle

Harvard

Rambaldi, D, Giorgi, FM, Capuani, F, Ciliberto, A & Ciccarelli, FD 2008, 'Low duplicability and network fragility of cancer genes', Trends in Genetics, vol. 24, no. 9, N/A, pp. 427-430. https://doi.org/10.1016/j.tig.2008.06.003

APA

Rambaldi, D., Giorgi, F. M., Capuani, F., Ciliberto, A., & Ciccarelli, F. D. (2008). Low duplicability and network fragility of cancer genes. Trends in Genetics, 24(9), 427-430. [N/A]. https://doi.org/10.1016/j.tig.2008.06.003

Vancouver

Rambaldi D, Giorgi FM, Capuani F, Ciliberto A, Ciccarelli FD. Low duplicability and network fragility of cancer genes. Trends in Genetics. 2008 Sep;24(9):427-430. N/A. https://doi.org/10.1016/j.tig.2008.06.003

Author

Rambaldi, Davide ; Giorgi, Federico M. ; Capuani, Fabrizio ; Ciliberto, Andrea ; Ciccarelli, Francesca D. / Low duplicability and network fragility of cancer genes. In: Trends in Genetics. 2008 ; Vol. 24, No. 9. pp. 427-430.

Bibtex Download

@article{6ab9443fd3a44708a7c9d38c53793f30,
title = "Low duplicability and network fragility of cancer genes",
abstract = "We identified genomic and network properties of ∼600 genes mutated in different cancer types. These genes tend not to duplicate but, unlike most human singletons, they encode central hubs of highly interconnected modules within the protein–protein interaction network (PIN). We find that cancer genes are fragile components of the human gene repertoire, sensitive to dosage modification. Furthermore, other nodes of the human PIN with similar properties are rare and probably enriched in candidate cancer genes.",
keywords = "Ciccarelli",
author = "Davide Rambaldi and Giorgi, {Federico M.} and Fabrizio Capuani and Andrea Ciliberto and Ciccarelli, {Francesca D.}",
year = "2008",
month = "9",
doi = "10.1016/j.tig.2008.06.003",
language = "English",
volume = "24",
pages = "427--430",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Limited",
number = "9",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Low duplicability and network fragility of cancer genes

AU - Rambaldi, Davide

AU - Giorgi, Federico M.

AU - Capuani, Fabrizio

AU - Ciliberto, Andrea

AU - Ciccarelli, Francesca D.

PY - 2008/9

Y1 - 2008/9

N2 - We identified genomic and network properties of ∼600 genes mutated in different cancer types. These genes tend not to duplicate but, unlike most human singletons, they encode central hubs of highly interconnected modules within the protein–protein interaction network (PIN). We find that cancer genes are fragile components of the human gene repertoire, sensitive to dosage modification. Furthermore, other nodes of the human PIN with similar properties are rare and probably enriched in candidate cancer genes.

AB - We identified genomic and network properties of ∼600 genes mutated in different cancer types. These genes tend not to duplicate but, unlike most human singletons, they encode central hubs of highly interconnected modules within the protein–protein interaction network (PIN). We find that cancer genes are fragile components of the human gene repertoire, sensitive to dosage modification. Furthermore, other nodes of the human PIN with similar properties are rare and probably enriched in candidate cancer genes.

KW - Ciccarelli

U2 - 10.1016/j.tig.2008.06.003

DO - 10.1016/j.tig.2008.06.003

M3 - Article

VL - 24

SP - 427

EP - 430

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 9

M1 - N/A

ER -

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