Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms

IMAGEN Consortium

doi:10.1016/j.bpsc.2019.02.006

Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms

IMAGEN Consortium

University of Vermont
Universitatsklinikum Mannheim
Department of Urology
Universitatsklinikum Hamburg-Eppendorf und Medizinische Fakultat
Medical Research Council–Social
King's College London
Département de Psychiatrie
University of Montreal
Heidelberg University
Neurospin, Commissariat Energie Atom
University of Nottingham
Institute for Radiology, CCM
Physikalisch-Technische Bundesanstalt
University of Paris XI - University of Paris-Sud
University Health Network, Toronto
Medical University of Vienna
TU Dresden
UCD Institute of Food and Health
Behavioral Neuroscience Branch NIDA-IRP

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Background: Studying the neural consequences of tobacco smoking during adolescence, including those associated with early light use, may help expose the mechanisms that underlie the transition from initial use to nicotine dependence in adulthood. However, only a few studies in adolescents exist, and they include small samples. In addition, the neural mechanism, if one exists, that links nicotinic receptor genes to smoking behavior in adolescents is still unknown. Methods: Structural and diffusion tensor magnetic resonance imaging data were acquired from a large sample of 14-year-old adolescents who completed an extensive battery of neuropsychological, clinical, personality, and drug-use assessments. Additional assessments were conducted at 16 years of age. Results: Exposure to smoking in adolescents, even at low doses, is linked to volume changes in the ventromedial prefrontal cortex and to altered neuronal connectivity in the corpus callosum. The longitudinal analyses strongly suggest that these effects are not preexisting conditions in those who progress to smoking. There was a genetic contribution wherein the volume reduction effects were magnified in smokers who were carriers of the high-risk genotype of the alpha 5 nicotinic receptor subunit gene, rs16969968. Conclusions: These findings give insight into a mechanism involving genes, brain structure, and connectivity underlying why some adolescents find nicotine especially addictive.

Original language	English
Pages (from-to)	672-679
Number of pages	8
Journal	Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Volume	4
Issue number	7
DOIs	https://doi.org/10.1016/j.bpsc.2019.02.006
Publication status	Published - 1 Jul 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adolescents
fMRI
Genetics
Gray matter volume
Low smoking exposure
Neuroimaging

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10.1016/j.bpsc.2019.02.006

Cite this

@article{ebe42fba59244aae90fe4f30033b9277,

title = "Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms",

abstract = "Background: Studying the neural consequences of tobacco smoking during adolescence, including those associated with early light use, may help expose the mechanisms that underlie the transition from initial use to nicotine dependence in adulthood. However, only a few studies in adolescents exist, and they include small samples. In addition, the neural mechanism, if one exists, that links nicotinic receptor genes to smoking behavior in adolescents is still unknown. Methods: Structural and diffusion tensor magnetic resonance imaging data were acquired from a large sample of 14-year-old adolescents who completed an extensive battery of neuropsychological, clinical, personality, and drug-use assessments. Additional assessments were conducted at 16 years of age. Results: Exposure to smoking in adolescents, even at low doses, is linked to volume changes in the ventromedial prefrontal cortex and to altered neuronal connectivity in the corpus callosum. The longitudinal analyses strongly suggest that these effects are not preexisting conditions in those who progress to smoking. There was a genetic contribution wherein the volume reduction effects were magnified in smokers who were carriers of the high-risk genotype of the alpha 5 nicotinic receptor subunit gene, rs16969968. Conclusions: These findings give insight into a mechanism involving genes, brain structure, and connectivity underlying why some adolescents find nicotine especially addictive.",

keywords = "Adolescents, fMRI, Genetics, Gray matter volume, Low smoking exposure, Neuroimaging",

author = "Bader Chaarani and Kan, \{Kees Jan\} and Scott Mackey and Spechler, \{Philip A.\} and Alexandra Potter and Catherine Orr and Nicholas D'Alberto and Hudson, \{Kelsey E.\} and Tobias Banaschewski and Bokde, \{Arun L.W.\} and Uli Bromberg and Christian B{\"u}chel and Anna Cattrell and Conrod, \{Patricia J.\} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and J{\"u}rgen Gallinat and Penny Gowland and Andreas Heinz and Bernd Ittermann and Martinot, \{Jean Luc\} and Frauke Nees and Dimitri Papadopoulos-Orfanos and Tom{\'a}{\v s} Paus and Luise Poustka and Smolka, \{Michael N.\} and Henrik Walter and Robert Whelan and Higgins, \{Stephen T.\} and Gunter Schumann and Althoff, \{Robert R.\} and Stein, \{Elliot A.\} and Hugh Garavan and Karl Mann and Maren Struve and Marcella Rietschel and Rainer Spanagel and Jan Reuter and Tianye Jia and Helen Werts and Lauren Topper and Laurence Reed and Catherine Mallik and Barbara Ruggeri and Charlotte Nymberg and Lindsay Smith and Eva Loth and Argyris Stringaris and Craig Newman and \{IMAGEN Consortium\}",

year = "2019",

month = jul,

day = "1",

doi = "10.1016/j.bpsc.2019.02.006",

language = "English",

volume = "4",

pages = "672--679",

journal = "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",

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T1 - Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms

AU - Chaarani, Bader

AU - Kan, Kees Jan

AU - Mackey, Scott

AU - Spechler, Philip A.

AU - Potter, Alexandra

AU - Orr, Catherine

AU - D'Alberto, Nicholas

AU - Hudson, Kelsey E.

AU - Banaschewski, Tobias

AU - Bokde, Arun L.W.

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia J.

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean Luc

AU - Nees, Frauke

AU - Papadopoulos-Orfanos, Dimitri

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Smolka, Michael N.

AU - Walter, Henrik

AU - Whelan, Robert

AU - Higgins, Stephen T.

AU - Schumann, Gunter

AU - Althoff, Robert R.

AU - Stein, Elliot A.

AU - Garavan, Hugh

AU - Mann, Karl

AU - Struve, Maren

AU - Rietschel, Marcella

AU - Spanagel, Rainer

AU - Reuter, Jan

AU - Jia, Tianye

AU - Werts, Helen

AU - Topper, Lauren

AU - Reed, Laurence

AU - Mallik, Catherine

AU - Ruggeri, Barbara

AU - Nymberg, Charlotte

AU - Smith, Lindsay

AU - Loth, Eva

AU - Stringaris, Argyris

AU - Newman, Craig

AU - IMAGEN Consortium

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: Studying the neural consequences of tobacco smoking during adolescence, including those associated with early light use, may help expose the mechanisms that underlie the transition from initial use to nicotine dependence in adulthood. However, only a few studies in adolescents exist, and they include small samples. In addition, the neural mechanism, if one exists, that links nicotinic receptor genes to smoking behavior in adolescents is still unknown. Methods: Structural and diffusion tensor magnetic resonance imaging data were acquired from a large sample of 14-year-old adolescents who completed an extensive battery of neuropsychological, clinical, personality, and drug-use assessments. Additional assessments were conducted at 16 years of age. Results: Exposure to smoking in adolescents, even at low doses, is linked to volume changes in the ventromedial prefrontal cortex and to altered neuronal connectivity in the corpus callosum. The longitudinal analyses strongly suggest that these effects are not preexisting conditions in those who progress to smoking. There was a genetic contribution wherein the volume reduction effects were magnified in smokers who were carriers of the high-risk genotype of the alpha 5 nicotinic receptor subunit gene, rs16969968. Conclusions: These findings give insight into a mechanism involving genes, brain structure, and connectivity underlying why some adolescents find nicotine especially addictive.

AB - Background: Studying the neural consequences of tobacco smoking during adolescence, including those associated with early light use, may help expose the mechanisms that underlie the transition from initial use to nicotine dependence in adulthood. However, only a few studies in adolescents exist, and they include small samples. In addition, the neural mechanism, if one exists, that links nicotinic receptor genes to smoking behavior in adolescents is still unknown. Methods: Structural and diffusion tensor magnetic resonance imaging data were acquired from a large sample of 14-year-old adolescents who completed an extensive battery of neuropsychological, clinical, personality, and drug-use assessments. Additional assessments were conducted at 16 years of age. Results: Exposure to smoking in adolescents, even at low doses, is linked to volume changes in the ventromedial prefrontal cortex and to altered neuronal connectivity in the corpus callosum. The longitudinal analyses strongly suggest that these effects are not preexisting conditions in those who progress to smoking. There was a genetic contribution wherein the volume reduction effects were magnified in smokers who were carriers of the high-risk genotype of the alpha 5 nicotinic receptor subunit gene, rs16969968. Conclusions: These findings give insight into a mechanism involving genes, brain structure, and connectivity underlying why some adolescents find nicotine especially addictive.

KW - Adolescents

KW - fMRI

KW - Genetics

KW - Gray matter volume

KW - Low smoking exposure

KW - Neuroimaging

UR - https://www.scopus.com/pages/publications/85065211708

U2 - 10.1016/j.bpsc.2019.02.006

DO - 10.1016/j.bpsc.2019.02.006

M3 - Article

AN - SCOPUS:85065211708

SN - 2451-9022

VL - 4

SP - 672

EP - 679

JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

IS - 7

ER -

Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms

Abstract

UN SDGs

Keywords

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