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Lower Bone Mineral Density at the Hip and Lumbar Spine in People with Psychosis Versus Controls: a Comprehensive Review and Skeletal Site-Specific Meta-analysis

Research output: Contribution to journalArticle

Standard

Lower Bone Mineral Density at the Hip and Lumbar Spine in People with Psychosis Versus Controls : a Comprehensive Review and Skeletal Site-Specific Meta-analysis. / Gomez, Lucia; Stubbs, Brendon; Shirazi, Ayala; Vancampfort, Davy; Gaughran, Fiona; Lally, John.

In: Current osteoporosis reports, 01.10.2016.

Research output: Contribution to journalArticle

Harvard

Gomez, L, Stubbs, B, Shirazi, A, Vancampfort, D, Gaughran, F & Lally, J 2016, 'Lower Bone Mineral Density at the Hip and Lumbar Spine in People with Psychosis Versus Controls: a Comprehensive Review and Skeletal Site-Specific Meta-analysis', Current osteoporosis reports. https://doi.org/10.1007/s11914-016-0325-0

APA

Gomez, L., Stubbs, B., Shirazi, A., Vancampfort, D., Gaughran, F., & Lally, J. (2016). Lower Bone Mineral Density at the Hip and Lumbar Spine in People with Psychosis Versus Controls: a Comprehensive Review and Skeletal Site-Specific Meta-analysis. Current osteoporosis reports. https://doi.org/10.1007/s11914-016-0325-0

Vancouver

Gomez L, Stubbs B, Shirazi A, Vancampfort D, Gaughran F, Lally J. Lower Bone Mineral Density at the Hip and Lumbar Spine in People with Psychosis Versus Controls: a Comprehensive Review and Skeletal Site-Specific Meta-analysis. Current osteoporosis reports. 2016 Oct 1. https://doi.org/10.1007/s11914-016-0325-0

Author

Gomez, Lucia ; Stubbs, Brendon ; Shirazi, Ayala ; Vancampfort, Davy ; Gaughran, Fiona ; Lally, John. / Lower Bone Mineral Density at the Hip and Lumbar Spine in People with Psychosis Versus Controls : a Comprehensive Review and Skeletal Site-Specific Meta-analysis. In: Current osteoporosis reports. 2016.

Bibtex Download

@article{596fe9d0538c4cf190a5e424d8cbdfc0,
title = "Lower Bone Mineral Density at the Hip and Lumbar Spine in People with Psychosis Versus Controls: a Comprehensive Review and Skeletal Site-Specific Meta-analysis",
abstract = "It remains unclear if differences in bone mineral density (BMD) exist at different skeletal sites between people with schizophrenia and age- and sex-matched healthy controls (HCs). Major databases were searched from inception until February 2016 for studies measuring BMD using dual-energy X-ray absorptiometry (DXA) at any skeletal site in individuals with schizophrenia. Ten studies investigating 827 people with schizophrenia (55.4 % female, 33.8 ± 9.7 years) and 1379 HCs (58.7 % female, 34.7 ± 9.1 years) were included. People with schizophrenia had significantly reduced BMD at the lumbar spine (standardised mean difference adjusted for publication bias (SMD) = -0.950 (95 % CI = -1.23 to -0.66, fail-safe number = 825) and hip (SMD = -0.534, 95 % CI = -0.876 to -0.192, fail-safe number = 186). A higher proportion of hyperprolactinaemia (β = -0.0102, p < 0.0001) and smokers (β = -0.0099, p = 0.02) moderated a larger reduced BMD at the lumbar spine. Further research is required to investigate if low bone mass and fractures can be prevented in people with schizophrenia.",
author = "Lucia Gomez and Brendon Stubbs and Ayala Shirazi and Davy Vancampfort and Fiona Gaughran and John Lally",
year = "2016",
month = oct,
day = "1",
doi = "10.1007/s11914-016-0325-0",
language = "English",
journal = "Current osteoporosis reports",
issn = "1544-2241",
publisher = "Current Science, Inc.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Lower Bone Mineral Density at the Hip and Lumbar Spine in People with Psychosis Versus Controls

T2 - a Comprehensive Review and Skeletal Site-Specific Meta-analysis

AU - Gomez, Lucia

AU - Stubbs, Brendon

AU - Shirazi, Ayala

AU - Vancampfort, Davy

AU - Gaughran, Fiona

AU - Lally, John

PY - 2016/10/1

Y1 - 2016/10/1

N2 - It remains unclear if differences in bone mineral density (BMD) exist at different skeletal sites between people with schizophrenia and age- and sex-matched healthy controls (HCs). Major databases were searched from inception until February 2016 for studies measuring BMD using dual-energy X-ray absorptiometry (DXA) at any skeletal site in individuals with schizophrenia. Ten studies investigating 827 people with schizophrenia (55.4 % female, 33.8 ± 9.7 years) and 1379 HCs (58.7 % female, 34.7 ± 9.1 years) were included. People with schizophrenia had significantly reduced BMD at the lumbar spine (standardised mean difference adjusted for publication bias (SMD) = -0.950 (95 % CI = -1.23 to -0.66, fail-safe number = 825) and hip (SMD = -0.534, 95 % CI = -0.876 to -0.192, fail-safe number = 186). A higher proportion of hyperprolactinaemia (β = -0.0102, p < 0.0001) and smokers (β = -0.0099, p = 0.02) moderated a larger reduced BMD at the lumbar spine. Further research is required to investigate if low bone mass and fractures can be prevented in people with schizophrenia.

AB - It remains unclear if differences in bone mineral density (BMD) exist at different skeletal sites between people with schizophrenia and age- and sex-matched healthy controls (HCs). Major databases were searched from inception until February 2016 for studies measuring BMD using dual-energy X-ray absorptiometry (DXA) at any skeletal site in individuals with schizophrenia. Ten studies investigating 827 people with schizophrenia (55.4 % female, 33.8 ± 9.7 years) and 1379 HCs (58.7 % female, 34.7 ± 9.1 years) were included. People with schizophrenia had significantly reduced BMD at the lumbar spine (standardised mean difference adjusted for publication bias (SMD) = -0.950 (95 % CI = -1.23 to -0.66, fail-safe number = 825) and hip (SMD = -0.534, 95 % CI = -0.876 to -0.192, fail-safe number = 186). A higher proportion of hyperprolactinaemia (β = -0.0102, p < 0.0001) and smokers (β = -0.0099, p = 0.02) moderated a larger reduced BMD at the lumbar spine. Further research is required to investigate if low bone mass and fractures can be prevented in people with schizophrenia.

U2 - 10.1007/s11914-016-0325-0

DO - 10.1007/s11914-016-0325-0

M3 - Article

C2 - 27696144

JO - Current osteoporosis reports

JF - Current osteoporosis reports

SN - 1544-2241

ER -

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