LOWERing the INtensity of oral anticoaGulant Therapy in patients with bileaflet mechanical aortic valve replacement: results from the "LOWERING-IT" Trial

Michele Torella, Daniele Torella, Paolo Chiodini, Marco Franciulli, Giampaolo Romano, Luca De Santo, Marisa De Feo, Cristiano Amarelli, Ferdinando C Sasso, Teresa Salvatore, Georgina M Ellison, Ciro Indolfi, Maurizio Cotrufo, Gianantonio Nappi

    Research output: Contribution to journalArticlepeer-review

    95 Citations (Scopus)

    Abstract

    Moderate anticoagulation after mechanical heart valve replacement has been proposed to reduce the risk of bleeding related to lifelong anticoagulation. However, the efficacy of such reduced antithrombotic regimens is still unknown. The present prospective open-label, single-center, randomized controlled trial aimed to evaluate the safety and feasibility of reduced oral anticoagulation after isolated mechanical aortic valve replacement.
    Original languageEnglish
    Pages (from-to)171-8
    Number of pages8
    JournalAmerican Heart Journal
    Volume160
    Issue number1
    DOIs
    Publication statusPublished - Jul 2010

    Keywords

    • Administration, Oral
    • Young Adult
    • Anticoagulants
    • Dose-Response Relationship, Drug
    • Humans
    • Prognosis
    • Postoperative Hemorrhage
    • Thrombosis
    • Italy
    • Prospective Studies
    • Risk Factors
    • Adult
    • Heart Valve Prosthesis
    • Prosthesis Design
    • Incidence
    • Follow-Up Studies
    • Middle Aged
    • Aortic Valve Stenosis
    • Female
    • Male

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