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Lung function and respiratory outcomes in teenage boys and girls born very prematurely: Prematurity, sex and respiratory outcome

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Lung function and respiratory outcomes in teenage boys and girls born very prematurely : Prematurity, sex and respiratory outcome. / Harris, Christopher; Zivanovic, Sanja; Lunt, Alan; Calvert, Sandy; Bisquera, Alessandra; Marlow, Neil; Peacock, Janet L; Greenough, Anne.

In: Pediatric Pulmonology, Vol. 55, No. 3, 01.03.2020, p. 682-689.

Research output: Contribution to journalArticle

Harvard

Harris, C, Zivanovic, S, Lunt, A, Calvert, S, Bisquera, A, Marlow, N, Peacock, JL & Greenough, A 2020, 'Lung function and respiratory outcomes in teenage boys and girls born very prematurely: Prematurity, sex and respiratory outcome', Pediatric Pulmonology, vol. 55, no. 3, pp. 682-689. https://doi.org/10.1002/ppul.24631

APA

Harris, C., Zivanovic, S., Lunt, A., Calvert, S., Bisquera, A., Marlow, N., ... Greenough, A. (2020). Lung function and respiratory outcomes in teenage boys and girls born very prematurely: Prematurity, sex and respiratory outcome. Pediatric Pulmonology, 55(3), 682-689. https://doi.org/10.1002/ppul.24631

Vancouver

Harris C, Zivanovic S, Lunt A, Calvert S, Bisquera A, Marlow N et al. Lung function and respiratory outcomes in teenage boys and girls born very prematurely: Prematurity, sex and respiratory outcome. Pediatric Pulmonology. 2020 Mar 1;55(3):682-689. https://doi.org/10.1002/ppul.24631

Author

Harris, Christopher ; Zivanovic, Sanja ; Lunt, Alan ; Calvert, Sandy ; Bisquera, Alessandra ; Marlow, Neil ; Peacock, Janet L ; Greenough, Anne. / Lung function and respiratory outcomes in teenage boys and girls born very prematurely : Prematurity, sex and respiratory outcome. In: Pediatric Pulmonology. 2020 ; Vol. 55, No. 3. pp. 682-689.

Bibtex Download

@article{b253cf6524d942efa118b07df79f4927,
title = "Lung function and respiratory outcomes in teenage boys and girls born very prematurely: Prematurity, sex and respiratory outcome",
abstract = "ObjectivesMale sex in prematurely born infants has been associated with worse respiratory outcomes in early childhood.Working HypothesisRespiratory outcomes at 11 to 14 years of age in children born very prematurely and routinely exposed to antenatal corticosteroids and postnatal surfactant would differ according to sex.Study DesignAnalysis of follow‐up data.Patient‐Subject SelectionThree hundred and nineteen children born before 29 weeks of gestational age from the United Kingdom Oscillation Study.MethodologySpirometry was used to assess forced expiratory flow at 75{\%}, 50{\%}, and 25{\%} of expired vital capacity (FEF75, FEF50, and FEF25), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and forced vital capacity (FVC). Lung volumes were measured using a helium dilution technique (FRCHe) and by plethysmography (FRCpleth). Total lung capacity (TLC) and residual volume (RV) were calculated. Mean lung function measurements were compared using linear mixed models and reported as unadjusted and adjusted for neonatal and age 11 to 14 years factors. The participants also completed health questionnaires and provided a urine sample for assessment of passive or active smoking.ResultsThree (FEF25, FEF25‐75, FEV1) lung function measures showed significant differences in favor of females after adjustment. The percentage of children with abnormal lung function (below 5th centile for normal) had adjusted differences between 10 and 30 percentage points, for example, for FEF25 15{\%} females compared with 26{\%} males.ConclusionsAmong extremely prematurely born school children airway function was significantly worse in males.",
keywords = "prematurity, respiratory function, sex",
author = "Christopher Harris and Sanja Zivanovic and Alan Lunt and Sandy Calvert and Alessandra Bisquera and Neil Marlow and Peacock, {Janet L} and Anne Greenough",
year = "2020",
month = "3",
day = "1",
doi = "10.1002/ppul.24631",
language = "English",
volume = "55",
pages = "682--689",
journal = "Pediatric Pulmonology",
issn = "8755-6863",
number = "3",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Lung function and respiratory outcomes in teenage boys and girls born very prematurely

T2 - Prematurity, sex and respiratory outcome

AU - Harris, Christopher

AU - Zivanovic, Sanja

AU - Lunt, Alan

AU - Calvert, Sandy

AU - Bisquera, Alessandra

AU - Marlow, Neil

AU - Peacock, Janet L

AU - Greenough, Anne

PY - 2020/3/1

Y1 - 2020/3/1

N2 - ObjectivesMale sex in prematurely born infants has been associated with worse respiratory outcomes in early childhood.Working HypothesisRespiratory outcomes at 11 to 14 years of age in children born very prematurely and routinely exposed to antenatal corticosteroids and postnatal surfactant would differ according to sex.Study DesignAnalysis of follow‐up data.Patient‐Subject SelectionThree hundred and nineteen children born before 29 weeks of gestational age from the United Kingdom Oscillation Study.MethodologySpirometry was used to assess forced expiratory flow at 75%, 50%, and 25% of expired vital capacity (FEF75, FEF50, and FEF25), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and forced vital capacity (FVC). Lung volumes were measured using a helium dilution technique (FRCHe) and by plethysmography (FRCpleth). Total lung capacity (TLC) and residual volume (RV) were calculated. Mean lung function measurements were compared using linear mixed models and reported as unadjusted and adjusted for neonatal and age 11 to 14 years factors. The participants also completed health questionnaires and provided a urine sample for assessment of passive or active smoking.ResultsThree (FEF25, FEF25‐75, FEV1) lung function measures showed significant differences in favor of females after adjustment. The percentage of children with abnormal lung function (below 5th centile for normal) had adjusted differences between 10 and 30 percentage points, for example, for FEF25 15% females compared with 26% males.ConclusionsAmong extremely prematurely born school children airway function was significantly worse in males.

AB - ObjectivesMale sex in prematurely born infants has been associated with worse respiratory outcomes in early childhood.Working HypothesisRespiratory outcomes at 11 to 14 years of age in children born very prematurely and routinely exposed to antenatal corticosteroids and postnatal surfactant would differ according to sex.Study DesignAnalysis of follow‐up data.Patient‐Subject SelectionThree hundred and nineteen children born before 29 weeks of gestational age from the United Kingdom Oscillation Study.MethodologySpirometry was used to assess forced expiratory flow at 75%, 50%, and 25% of expired vital capacity (FEF75, FEF50, and FEF25), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and forced vital capacity (FVC). Lung volumes were measured using a helium dilution technique (FRCHe) and by plethysmography (FRCpleth). Total lung capacity (TLC) and residual volume (RV) were calculated. Mean lung function measurements were compared using linear mixed models and reported as unadjusted and adjusted for neonatal and age 11 to 14 years factors. The participants also completed health questionnaires and provided a urine sample for assessment of passive or active smoking.ResultsThree (FEF25, FEF25‐75, FEV1) lung function measures showed significant differences in favor of females after adjustment. The percentage of children with abnormal lung function (below 5th centile for normal) had adjusted differences between 10 and 30 percentage points, for example, for FEF25 15% females compared with 26% males.ConclusionsAmong extremely prematurely born school children airway function was significantly worse in males.

KW - prematurity

KW - respiratory function

KW - sex

UR - http://www.scopus.com/inward/record.url?scp=85077858692&partnerID=8YFLogxK

U2 - 10.1002/ppul.24631

DO - 10.1002/ppul.24631

M3 - Article

C2 - 31910333

VL - 55

SP - 682

EP - 689

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

SN - 8755-6863

IS - 3

ER -

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