Lung function at 16–19 years in males and females born very prematurely: Lung function in males and females born preterm

TY - JOUR

T1 - Lung function at 16–19 years in males and females born very prematurely

T2 - Lung function in males and females born preterm

AU - Harris, Christopher

AU - Lunt, Alan

AU - Peacock, Janet

AU - Greenough, Anne

N1 - Funding Information: The authors would like to thank Daniel and Kristina Ogunmade and their twins Lochlan and Greer who were looked after on the neonatal intensive care unit for their support of our research. The Lochlan and Greer Foundation and BlackRock UK. This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas’ NHS Foundation Trust and King's College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. Funding Information: The authors would like to thank Daniel and Kristina Ogunmade and their twins Lochlan and Greer who were looked after on the neonatal intensive care unit for their support of our research. The Lochlan and Greer Foundation and BlackRock UK. This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas’ NHS Foundation Trust and King's College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. Publisher Copyright: © 2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.

PY - 2023/7

Y1 - 2023/7

N2 - Objectives: To determine if there were differences in lung function at 16–19 years of age between males and females born very prematurely. Working Hypothesis: Females compared with males would have superior lung function and exercise capacity. Study Design: Cohort study. Patient-Subject Selection: Those born at less than 29 weeks of gestational age. Methodology: Lung function testing (spirometry, oscillometry, diffusion capacity, lung clearance index, and plethysmography), a shuttle sprint test for exercise capacity, and a respiratory symptoms questionnaire. Results: Amongst 150 participants, males had poorer lung function compared with females with mean z score differences (95% CI [confidence interval]) after adjustment: forced expiratory flow at 75% (FEF 75) (–0.60 [–0.97,–0.24]), forced expiratory flow at 50% (FEF 50) (−0.39 [−0.72,−0.07]), forced expiratory flow at 25%–75% (FEF 25-75) (−0.62 [−0.98,−0.26]), the ratio of the forced expiratory volume in the first one second to the forced vital capacity of the lungs (FEV 1:FVC ratio) (−0.71 [−1.09,−0.34]), diffusing capacity of the lungs for carbon monoxide (DLCO) (−0.41 [−0.78,−0.03]), diffusing capacity of the lung for carbon monoxide divided by alveolar volume (DLCO/VA) (−0.57 [−0.86,−0.28]). Exercise capacity and self-reported exercise were both significantly better in males than females (46% males achieving between 1250 and 1500 m shuttle sprint distance vs. 4.8% females) and 74% males versus 67% females undertaking some exercise. There were no significant differences by sex in the prevalence of either wheeze or current asthma. Conclusions: Males had poorer lung function than females at age 16–19 years, but their exercise capacity was superior to females.

AB - Objectives: To determine if there were differences in lung function at 16–19 years of age between males and females born very prematurely. Working Hypothesis: Females compared with males would have superior lung function and exercise capacity. Study Design: Cohort study. Patient-Subject Selection: Those born at less than 29 weeks of gestational age. Methodology: Lung function testing (spirometry, oscillometry, diffusion capacity, lung clearance index, and plethysmography), a shuttle sprint test for exercise capacity, and a respiratory symptoms questionnaire. Results: Amongst 150 participants, males had poorer lung function compared with females with mean z score differences (95% CI [confidence interval]) after adjustment: forced expiratory flow at 75% (FEF 75) (–0.60 [–0.97,–0.24]), forced expiratory flow at 50% (FEF 50) (−0.39 [−0.72,−0.07]), forced expiratory flow at 25%–75% (FEF 25-75) (−0.62 [−0.98,−0.26]), the ratio of the forced expiratory volume in the first one second to the forced vital capacity of the lungs (FEV 1:FVC ratio) (−0.71 [−1.09,−0.34]), diffusing capacity of the lungs for carbon monoxide (DLCO) (−0.41 [−0.78,−0.03]), diffusing capacity of the lung for carbon monoxide divided by alveolar volume (DLCO/VA) (−0.57 [−0.86,−0.28]). Exercise capacity and self-reported exercise were both significantly better in males than females (46% males achieving between 1250 and 1500 m shuttle sprint distance vs. 4.8% females) and 74% males versus 67% females undertaking some exercise. There were no significant differences by sex in the prevalence of either wheeze or current asthma. Conclusions: Males had poorer lung function than females at age 16–19 years, but their exercise capacity was superior to females.

UR - http://www.scopus.com/inward/record.url?scp=85158124503&partnerID=8YFLogxK

U2 - 10.1002/ppul.26428

DO - 10.1002/ppul.26428

M3 - Article

SN - 8755-6863

VL - 58

SP - 2035

EP - 2041

JO - Pediatric pulmonology

JF - Pediatric pulmonology

IS - 7

ER -