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Lung Protection During Mechanical Ventilation in the Premature Infant

Research output: Contribution to journalArticlepeer-review

Emma E. Williams, Anne Greenough

Original languageEnglish
Pages (from-to)869-880
Number of pages12
JournalClinics in Perinatology
Volume48
Issue number4
Early online date2 Oct 2021
DOIs
Accepted/In press2021
E-pub ahead of print2 Oct 2021
PublishedDec 2021

Bibliographical note

Funding Information: Professor A. Greenough has held grants from various manufacturers (Abbot Laboratories, MedImmune) and ventilator manufacturers (SLE). Professor A. Greenough has received honoraria for giving lectures and advising various manufacturers (Abbot Laboratories, MedImmune) and ventilator manufacturers (SLE). Professor A. Greenough is currently receiving a nonconditional educational grant from SLE. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

Mechanical ventilation can be life-saving for the premature infant, but is often injurious to immature and underdeveloped lungs. Lung injury is caused by atelectrauma, oxygen toxicity, and volutrauma. Lung protection must include appropriate lung recruitment starting in the delivery suite and throughout mechanical ventilation. Strategies include open lung ventilation, positive end-expiratory pressure, and volume-targeted ventilation. Respiratory function monitoring, such as capnography and ventilator graphics, provides clinicians with continuous real-time information and an adjunct to optimize lung-protective ventilatory strategies. Further research is needed to assess which lung-protective strategies result in a decrease in long-term respiratory morbidity. [Abstract copyright: Copyright © 2021 Elsevier Inc. All rights reserved.]

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