Lung simulation to support non-invasive pulmonary blood flow measurement in Acute Respiratory Distress Syndrome in animals

TY - CHAP

T1 - Lung simulation to support non-invasive pulmonary blood flow measurement in Acute Respiratory Distress Syndrome in animals

AU - Tran, Minh C.

AU - Crockett, Douglas C.

AU - Joseph, Arun

AU - Formenti, Federico

AU - Phan, Phi A.

AU - Payne, Stephen J.

AU - Farmery, Andrew D.

N1 - Funding Information: Research supported by NIHR and MRC research grants. Publisher Copyright: © 2021 IEEE.

PY - 2021

Y1 - 2021

N2 - Patients undergoing mechanical lung ventilation are at risk of lung injury. A noninvasive bedside lung monitor may benefit these patients. The Inspired Sinewave Test (IST) can measure cardio-pulmonary parameters noninvasively. We propose a lung simulation to improve the measurement of pulmonary blood flow using IST. The new method was applied to 12 pigs' data before lung injury (control) and after lung injury (ARDS model). Results using the lung simulation shown improvements in correlation in both simulated data (R 2 increased from 0.98 to 1) and pigs' data (R 2 increased from <0.001 to 0.26). Paired blood flow measurements were performed by both the IST (noninvasive) and thermodilution (invasive). In the control group, the bias of the two methods was negligible (0.02L/min), and the limit of agreement was from -1.20 to 1.18 L/min. The bias was -0.68 L/min in the ARDS group and with a broader limit of agreement (-2.49 to 1.13 L/min).Clinical Relevance - the inspired sinewave test can be used to measure cardiac output noninvasively in mechanically ventilated subjects with and without acute respiratory distress syndrome.

AB - Patients undergoing mechanical lung ventilation are at risk of lung injury. A noninvasive bedside lung monitor may benefit these patients. The Inspired Sinewave Test (IST) can measure cardio-pulmonary parameters noninvasively. We propose a lung simulation to improve the measurement of pulmonary blood flow using IST. The new method was applied to 12 pigs' data before lung injury (control) and after lung injury (ARDS model). Results using the lung simulation shown improvements in correlation in both simulated data (R 2 increased from 0.98 to 1) and pigs' data (R 2 increased from <0.001 to 0.26). Paired blood flow measurements were performed by both the IST (noninvasive) and thermodilution (invasive). In the control group, the bias of the two methods was negligible (0.02L/min), and the limit of agreement was from -1.20 to 1.18 L/min. The bias was -0.68 L/min in the ARDS group and with a broader limit of agreement (-2.49 to 1.13 L/min).Clinical Relevance - the inspired sinewave test can be used to measure cardiac output noninvasively in mechanically ventilated subjects with and without acute respiratory distress syndrome.

UR - http://www.scopus.com/inward/record.url?scp=85122500045&partnerID=8YFLogxK

U2 - 10.1109/EMBC46164.2021.9630893

DO - 10.1109/EMBC46164.2021.9630893

M3 - Conference paper

C2 - 34891243

AN - SCOPUS:85122500045

T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

SP - 76

EP - 79

BT - 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021

Y2 - 1 November 2021 through 5 November 2021

ER -