Müller Glia Reactivity and Development of Gliosis in Response to Pathological Conditions

Anna B Graca, Claire Hippert, Rachael A Pearson

Research output: Contribution to journalReview articlepeer-review

41 Citations (Scopus)


Within the mammalian retina, both Müller glia and astrocytes display reactivity in response to many forms of retinal injury and disease in a process termed gliosis. Reactive gliosis is a complex process that is considered to represent a cellular response to protect the retina from further damage and to promote its repair following pathological insult. It includes morphological, biochemical and physiological changes, which may vary depending on the type and degree of the initial injury. Not only does gliosis have numerous triggers, but also there is a great degree of heterogeneity in the glial response, creating multiple levels of complexity. For these reasons, understanding the process of glial scar formation and how this process differs in different pathological conditions and finding strategies to circumvent these barriers represent major challenges to the advancement of many ocular therapies.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalAdvances in Experimental Medicine And Biology
Publication statusPublished - 2018


  • Animals
  • Astrocytes/physiology
  • Cicatrix/pathology
  • Cytokines/metabolism
  • Ependymoglial Cells/physiology
  • Gliosis/complications
  • Humans
  • Intercellular Signaling Peptides and Proteins/metabolism
  • Intermediate Filament Proteins/metabolism
  • Photoreceptor Cells, Vertebrate/transplantation
  • Retina/injuries
  • Retinal Detachment/etiology
  • Retinal Diseases/metabolism
  • Species Specificity
  • Vertebrates/physiology


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