Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth

Junpei Li, Eniola Olaleye, Xiaole Kong, Tao Zhou, Yongmin Ma, Jagoda Jurach, Osamah Al Rugaie, Robert Charles Hider, Guoqing Zhang, Selwa Alsam, Vincenzo Abbate

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7 Citations (Scopus)
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Abstract

A series of linear poly (glycidyl methacrylate) (PGMA) polymers were synthesized via RAFT polymerization and conjugated with amine-containing 3-hydroxypyridin-4-ones (HPOs) to generate a panel of HPO-containing materials with controlled structures and specific iron-binding functions. The structures of the resulting polymers were characterized via 1H NMR, GPC and FT-IR and their chelating capacity for iron was investigated using UV–Vis spectrophotometric titration of the iron(III) complexes. In vitro antimicrobial studies of selected ligand-containing homopolymers demonstrate that the homopolymers are capable of inhibiting the growth of methicillin-resistant Staphylococcus aureus (MRSA). It is proposed that the inhibition activity of MRSA is derived from the iron-chelating capability of the iron-binding polymers.
Original languageEnglish
Pages (from-to)64-72
JournalPolymer
Volume87
Early online date30 Jan 2016
DOIs
Publication statusPublished - 22 Mar 2016

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