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Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth

Research output: Contribution to journalArticle

Junpei Li, Eniola Olaleye, Xiaole Kong, Tao Zhou, Yongmin Ma, Jagoda Jurach, Osamah Al Rugaie, Robert Charles Hider, Guoqing Zhang, Selwa Alsam, Vincenzo Abbate

Original languageEnglish
Pages (from-to)64-72
JournalPolymer
Volume87
Early online date30 Jan 2016
DOIs
Publication statusPublished - 22 Mar 2016

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  • Manuscript

    Manuscript.docx, 4.22 MB, application/vnd.openxmlformats-officedocument.wordprocessingml.document

    26/01/2018

    Accepted author manuscript

King's Authors

Abstract

A series of linear poly (glycidyl methacrylate) (PGMA) polymers were synthesized via RAFT polymerization and conjugated with amine-containing 3-hydroxypyridin-4-ones (HPOs) to generate a panel of HPO-containing materials with controlled structures and specific iron-binding functions. The structures of the resulting polymers were characterized via 1H NMR, GPC and FT-IR and their chelating capacity for iron was investigated using UV–Vis spectrophotometric titration of the iron(III) complexes. In vitro antimicrobial studies of selected ligand-containing homopolymers demonstrate that the homopolymers are capable of inhibiting the growth of methicillin-resistant Staphylococcus aureus (MRSA). It is proposed that the inhibition activity of MRSA is derived from the iron-chelating capability of the iron-binding polymers.

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