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Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth

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Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth. / Li, Junpei; Olaleye, Eniola; Kong, Xiaole; Zhou, Tao; Ma, Yongmin; Jurach, Jagoda; Al Rugaie, Osamah; Hider, Robert Charles; Zhang, Guoqing; Alsam, Selwa; Abbate, Vincenzo.

In: Polymer, Vol. 87, 22.03.2016, p. 64-72.

Research output: Contribution to journalArticle

Harvard

Li, J, Olaleye, E, Kong, X, Zhou, T, Ma, Y, Jurach, J, Al Rugaie, O, Hider, RC, Zhang, G, Alsam, S & Abbate, V 2016, 'Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth', Polymer, vol. 87, pp. 64-72. https://doi.org/10.1016/j.polymer.2016.01.073

APA

Li, J., Olaleye, E., Kong, X., Zhou, T., Ma, Y., Jurach, J., Al Rugaie, O., Hider, R. C., Zhang, G., Alsam, S., & Abbate, V. (2016). Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth. Polymer, 87, 64-72. https://doi.org/10.1016/j.polymer.2016.01.073

Vancouver

Li J, Olaleye E, Kong X, Zhou T, Ma Y, Jurach J et al. Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth. Polymer. 2016 Mar 22;87:64-72. https://doi.org/10.1016/j.polymer.2016.01.073

Author

Li, Junpei ; Olaleye, Eniola ; Kong, Xiaole ; Zhou, Tao ; Ma, Yongmin ; Jurach, Jagoda ; Al Rugaie, Osamah ; Hider, Robert Charles ; Zhang, Guoqing ; Alsam, Selwa ; Abbate, Vincenzo. / Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth. In: Polymer. 2016 ; Vol. 87. pp. 64-72.

Bibtex Download

@article{7d21ab5f0c3c4353aee423d3cb854351,
title = "Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth",
abstract = "A series of linear poly (glycidyl methacrylate) (PGMA) polymers were synthesized via RAFT polymerization and conjugated with amine-containing 3-hydroxypyridin-4-ones (HPOs) to generate a panel of HPO-containing materials with controlled structures and specific iron-binding functions. The structures of the resulting polymers were characterized via 1H NMR, GPC and FT-IR and their chelating capacity for iron was investigated using UV–Vis spectrophotometric titration of the iron(III) complexes. In vitro antimicrobial studies of selected ligand-containing homopolymers demonstrate that the homopolymers are capable of inhibiting the growth of methicillin-resistant Staphylococcus aureus (MRSA). It is proposed that the inhibition activity of MRSA is derived from the iron-chelating capability of the iron-binding polymers.",
author = "Junpei Li and Eniola Olaleye and Xiaole Kong and Tao Zhou and Yongmin Ma and Jagoda Jurach and {Al Rugaie}, Osamah and Hider, {Robert Charles} and Guoqing Zhang and Selwa Alsam and Vincenzo Abbate",
year = "2016",
month = mar,
day = "22",
doi = "10.1016/j.polymer.2016.01.073",
language = "English",
volume = "87",
pages = "64--72",
journal = "Polymer",
issn = "0032-3861",
publisher = "Elsevier BV",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth

AU - Li, Junpei

AU - Olaleye, Eniola

AU - Kong, Xiaole

AU - Zhou, Tao

AU - Ma, Yongmin

AU - Jurach, Jagoda

AU - Al Rugaie, Osamah

AU - Hider, Robert Charles

AU - Zhang, Guoqing

AU - Alsam, Selwa

AU - Abbate, Vincenzo

PY - 2016/3/22

Y1 - 2016/3/22

N2 - A series of linear poly (glycidyl methacrylate) (PGMA) polymers were synthesized via RAFT polymerization and conjugated with amine-containing 3-hydroxypyridin-4-ones (HPOs) to generate a panel of HPO-containing materials with controlled structures and specific iron-binding functions. The structures of the resulting polymers were characterized via 1H NMR, GPC and FT-IR and their chelating capacity for iron was investigated using UV–Vis spectrophotometric titration of the iron(III) complexes. In vitro antimicrobial studies of selected ligand-containing homopolymers demonstrate that the homopolymers are capable of inhibiting the growth of methicillin-resistant Staphylococcus aureus (MRSA). It is proposed that the inhibition activity of MRSA is derived from the iron-chelating capability of the iron-binding polymers.

AB - A series of linear poly (glycidyl methacrylate) (PGMA) polymers were synthesized via RAFT polymerization and conjugated with amine-containing 3-hydroxypyridin-4-ones (HPOs) to generate a panel of HPO-containing materials with controlled structures and specific iron-binding functions. The structures of the resulting polymers were characterized via 1H NMR, GPC and FT-IR and their chelating capacity for iron was investigated using UV–Vis spectrophotometric titration of the iron(III) complexes. In vitro antimicrobial studies of selected ligand-containing homopolymers demonstrate that the homopolymers are capable of inhibiting the growth of methicillin-resistant Staphylococcus aureus (MRSA). It is proposed that the inhibition activity of MRSA is derived from the iron-chelating capability of the iron-binding polymers.

U2 - 10.1016/j.polymer.2016.01.073

DO - 10.1016/j.polymer.2016.01.073

M3 - Article

VL - 87

SP - 64

EP - 72

JO - Polymer

JF - Polymer

SN - 0032-3861

ER -

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