Macrophage response during axonal regeneration in the axolotl central and peripheral nervous system

P S Zammit, J D Clarke, J P Golding, I A Goodbrand, D A Tonge

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

We have used a monoclonal antibody (5F4) and Griffonia lectin to study the recruitment of macrophages after crushing axolotl central and peripheral axons. In both cases axonal regeneration begins within one to two days and, in the CNS, proceeds at a rate of about 0.05 mm per day. However, in the spinal cord, macrophage entry is restricted to the lesion site whilst in peripheral nerves macrophages rapidly enter the distal nerve stump after injury. These results suggest that the role (if any) played by macrophages during axonal regeneration may differ in these two situations.
Original languageEnglish
Pages (from-to)781-789
Number of pages9
JournalNeuroscience
Volume54
Issue number3
DOIs
Publication statusPublished - Jun 1993

Keywords

  • Macrophages
  • Animals
  • Spinal Cord
  • Recruitment, Neurophysiological
  • Histocytochemistry
  • Central Nervous System
  • Optic Nerve
  • Antibodies, Monoclonal
  • Peripheral Nerves
  • Nerve Regeneration
  • Axons
  • Ambystoma mexicanum
  • Immunohistochemistry

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