Macrophage response during axonal regeneration in the axolotl central and peripheral nervous system

TY - JOUR

T1 - Macrophage response during axonal regeneration in the axolotl central and peripheral nervous system

AU - Zammit, P S

AU - Clarke, J D

AU - Golding, J P

AU - Goodbrand, I A

AU - Tonge, D A

PY - 1993/6

Y1 - 1993/6

N2 - We have used a monoclonal antibody (5F4) and Griffonia lectin to study the recruitment of macrophages after crushing axolotl central and peripheral axons. In both cases axonal regeneration begins within one to two days and, in the CNS, proceeds at a rate of about 0.05 mm per day. However, in the spinal cord, macrophage entry is restricted to the lesion site whilst in peripheral nerves macrophages rapidly enter the distal nerve stump after injury. These results suggest that the role (if any) played by macrophages during axonal regeneration may differ in these two situations.

AB - We have used a monoclonal antibody (5F4) and Griffonia lectin to study the recruitment of macrophages after crushing axolotl central and peripheral axons. In both cases axonal regeneration begins within one to two days and, in the CNS, proceeds at a rate of about 0.05 mm per day. However, in the spinal cord, macrophage entry is restricted to the lesion site whilst in peripheral nerves macrophages rapidly enter the distal nerve stump after injury. These results suggest that the role (if any) played by macrophages during axonal regeneration may differ in these two situations.

KW - Macrophages

KW - Animals

KW - Spinal Cord

KW - Recruitment, Neurophysiological

KW - Histocytochemistry

KW - Central Nervous System

KW - Optic Nerve

KW - Antibodies, Monoclonal

KW - Peripheral Nerves

KW - Nerve Regeneration

KW - Axons

KW - Ambystoma mexicanum

KW - Immunohistochemistry

U2 - 10.1016/0306-4522(93)90247-D

DO - 10.1016/0306-4522(93)90247-D

M3 - Article

C2 - 8332261

SN - 0306-4522

VL - 54

SP - 781

EP - 789

JO - Neuroscience

JF - Neuroscience

IS - 3

ER -