@article{36fb56d45f6a472caece11d76882cfc9,
title = "Magnetic resonance elastography with guided pressure waves",
abstract = "Magnetic resonance elastography aims to non-invasively and remotely characterize the mechanical properties of living tissues. To quantitatively and regionally map the shear viscoelastic moduli in vivo, the technique must achieve proper mechanical excitation throughout the targeted tissues. Although it is straightforward, ante manibus, in close organs such as the liver or the breast, which practitioners clinically palpate already, it is somewhat fortunately highly challenging to trick the natural protective barriers of remote organs such as the brain. So far, mechanical waves have been induced in the latter by shaking the surrounding cranial bones. Here, the skull was circumvented by guiding pressure waves inside the subject's buccal cavity so mechanical waves could propagate from within through the brainstem up to the brain. Repeatable, reproducible and robust displacement fields were recorded in phantoms and in vivo by magnetic resonance elastography with guided pressure waves such that quantitative mechanical outcomes were extracted in the human brain.",
keywords = "biomechanics, brain, excitation, magnetic resonance elastography, MRI, pressure wave",
author = "Marion Tardieu and Najat Salameh and Line Souris and David Rousseau and Laur{\`e}ne Jourdain and Hanadi Skeif and Fran{\c c}ois Pr{\'e}vot and {de Rochefort}, Ludovic and Denis Ducreux and Bruno Louis and Philippe Garteiser and Ralph Sinkus and Luc Darrasse and Marie Poirier-Quinot and Xavier Ma{\^i}tre",
note = "Funding Information: We acknowledge the International Ocean Discovery Program (IODP) and the European Consortium for Ocean Research Drilling (ECORD) for drilling the Great Barrier Reef (IODP Expedition 325 – Great Barrier Reef Environmental Changes). We thank H. Fischer, M. K. Gagan and H. Kuhnert for early discussions, reviewers for comments, and Expedition 325 scientists for contributions to previous publications. This work received funding from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) ‐ project number 180346848, through Priority Programme 527 “IODP”. Financial support was also provided by the Australian Research Council (grant no. DP1094001). Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: {\textcopyright} 2022 John Wiley & Sons, Ltd.",
year = "2022",
month = jul,
doi = "10.1002/nbm.4701",
language = "English",
volume = "35",
journal = "NMR in Biomedicine",
issn = "0952-3480",
publisher = "John Wiley and sons",
number = "7",
}