King's College London

Research portal

Magnetic resonance imaging measurement of placental perfusion and oxygen saturation in early-onset fetal growth restriction

Research output: Contribution to journalArticlepeer-review

Standard

Magnetic resonance imaging measurement of placental perfusion and oxygen saturation in early-onset fetal growth restriction. / Aughwane, R.; Mufti, N.; Flouri, D. et al.

In: BJOG, Vol. 128, No. 2, 01.2021, p. 337-345.

Research output: Contribution to journalArticlepeer-review

Harvard

Aughwane, R, Mufti, N, Flouri, D, Maksym, K, Spencer, R, Sokolska, M, Kendall, G, Atkinson, D, Bainbridge, A, Deprest, J, Vercauteren, T, Ourselin, S, David, AL & Melbourne, A 2021, 'Magnetic resonance imaging measurement of placental perfusion and oxygen saturation in early-onset fetal growth restriction', BJOG, vol. 128, no. 2, pp. 337-345. https://doi.org/10.1111/1471-0528.16387

APA

Aughwane, R., Mufti, N., Flouri, D., Maksym, K., Spencer, R., Sokolska, M., Kendall, G., Atkinson, D., Bainbridge, A., Deprest, J., Vercauteren, T., Ourselin, S., David, A. L., & Melbourne, A. (2021). Magnetic resonance imaging measurement of placental perfusion and oxygen saturation in early-onset fetal growth restriction. BJOG, 128(2), 337-345. https://doi.org/10.1111/1471-0528.16387

Vancouver

Aughwane R, Mufti N, Flouri D, Maksym K, Spencer R, Sokolska M et al. Magnetic resonance imaging measurement of placental perfusion and oxygen saturation in early-onset fetal growth restriction. BJOG. 2021 Jan;128(2):337-345. https://doi.org/10.1111/1471-0528.16387

Author

Aughwane, R. ; Mufti, N. ; Flouri, D. et al. / Magnetic resonance imaging measurement of placental perfusion and oxygen saturation in early-onset fetal growth restriction. In: BJOG. 2021 ; Vol. 128, No. 2. pp. 337-345.

Bibtex Download

@article{1cd55c17dd444cc1874fea7bafd2858d,
title = "Magnetic resonance imaging measurement of placental perfusion and oxygen saturation in early-onset fetal growth restriction",
abstract = "Objective: We hypothesised that a multi-compartment magnetic resonance imaging (MRI) technique that is sensitive to fetal blood oxygenation would identify changes in placental blood volume and fetal blood oxygenation in pregnancies complicated by early-onset fetal growth restriction (FGR). Design: Case–control study. Setting: London, UK. Population: Women with uncomplicated pregnancies (estimated fetal weight [EFW] >10th centile for gestational age [GA] and normal maternal and fetal Doppler ultrasound, n = 12) or early-onset FGR (EFW <3rd centile with or without abnormal Doppler ultrasound <32 weeks GA, n = 12) were studied. Methods: All women underwent MRI examination. Using a multi-compartment MRI technique, we quantified fetal and maternal blood volume and feto-placental blood oxygenation. Main outcome measures: Disease severity was stratified according to Doppler pulsatility index and the relationship to the MRI parameters was investigated, including the influence of GA at scan. Results: The FGR group (mean GA 27 +5 weeks, range 24 +2 to 33 +6 weeks) had a significantly lower EFW compared with the control group (mean GA 29 +1 weeks; −705 g, 95% CI −353 to −1057 g). MRI-derived feto-placental oxygen saturation was higher in controls compared with FGR (75 ± 9.6% versus 56 ± 16.2%, P = 0.02, 95% CI 7.8–30.3%). Feto-placental oxygen saturation estimation correlated strongly with GA at scan in controls (r = −0.83). Conclusion: Using a novel multimodal MRI protocol we demonstrated reduced feto-placental blood oxygen saturation in pregnancies complicated by early-onset FGR. The degree of abnormality correlated with disease severity defined by ultrasound Doppler findings. Gestational age-dependent changes in oxygen saturation were also present in normal pregnancies. Tweetable abstract: MRI reveals differences in feto-placental oxygen saturation between normal and FGR pregnancy that is associated with disease severity. ",
keywords = "Fetal growth restriction, oxygenation, placenta, pregnancy, relaxometry",
author = "R. Aughwane and N. Mufti and D. Flouri and K. Maksym and R. Spencer and M. Sokolska and G. Kendall and D. Atkinson and A. Bainbridge and J. Deprest and T. Vercauteren and S. Ourselin and David, {A. L.} and A. Melbourne",
note = "Funding Information: Dr Atkinson reports grants from Wellcome Trust/UK EPSRC, during the conduct of the study; Dr Spencer reports grants from Wellcome Trust, grants from Radiological Research Trust during the conduct of the study. Prof. David reports grants from Wellcome Trust (203148/Z/16/Z; 203145Z/16/Z; WT101957) and the Engineering and Physical Sciences Research Council (NS/A000049/1; NS/A000050/1; NS/A000027/1; EP/L016478/1) during the conduct of the study. The remaining authors have no disclosures. Completed disclosure of interests forms are available to view online as supporting information. Prof. Ourselin reports grants from Wellcome, grants from EPSRC, during the conduct of the study. Funding Information: This research was supported by the Wellcome Trust (210182/Z/18/Z and Wellcome Trust/EPSRC NS/A000027/1) and the Radiological Research Trust. The funders had no direction in the study design, data collection, data analysis, manuscript preparation or publication decision. Funding Information: This research was supported by the Wellcome Trust (210182/Z/18/Z and Wellcome Trust/EPSRC NS/A000027/1) and the Radiological Research Trust. The funders had no direction in the study design, data collection, data analysis, manuscript preparation or publication decision. This research was supported by the Wellcome Trust (210182/Z/18/Z and Wellcome Trust/EPSRC NS/A000027/1) and the Radiological Research Trust. The funders had no direction in the study design, data collection, data analysis, manuscript preparation or publication decision. Publisher Copyright: {\textcopyright} 2020 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jan,
doi = "10.1111/1471-0528.16387",
language = "English",
volume = "128",
pages = "337--345",
journal = "BJOG",
issn = "1470-0328",
publisher = "Blackwell Publishing Ltd",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Magnetic resonance imaging measurement of placental perfusion and oxygen saturation in early-onset fetal growth restriction

AU - Aughwane, R.

AU - Mufti, N.

AU - Flouri, D.

AU - Maksym, K.

AU - Spencer, R.

AU - Sokolska, M.

AU - Kendall, G.

AU - Atkinson, D.

AU - Bainbridge, A.

AU - Deprest, J.

AU - Vercauteren, T.

AU - Ourselin, S.

AU - David, A. L.

AU - Melbourne, A.

N1 - Funding Information: Dr Atkinson reports grants from Wellcome Trust/UK EPSRC, during the conduct of the study; Dr Spencer reports grants from Wellcome Trust, grants from Radiological Research Trust during the conduct of the study. Prof. David reports grants from Wellcome Trust (203148/Z/16/Z; 203145Z/16/Z; WT101957) and the Engineering and Physical Sciences Research Council (NS/A000049/1; NS/A000050/1; NS/A000027/1; EP/L016478/1) during the conduct of the study. The remaining authors have no disclosures. Completed disclosure of interests forms are available to view online as supporting information. Prof. Ourselin reports grants from Wellcome, grants from EPSRC, during the conduct of the study. Funding Information: This research was supported by the Wellcome Trust (210182/Z/18/Z and Wellcome Trust/EPSRC NS/A000027/1) and the Radiological Research Trust. The funders had no direction in the study design, data collection, data analysis, manuscript preparation or publication decision. Funding Information: This research was supported by the Wellcome Trust (210182/Z/18/Z and Wellcome Trust/EPSRC NS/A000027/1) and the Radiological Research Trust. The funders had no direction in the study design, data collection, data analysis, manuscript preparation or publication decision. This research was supported by the Wellcome Trust (210182/Z/18/Z and Wellcome Trust/EPSRC NS/A000027/1) and the Radiological Research Trust. The funders had no direction in the study design, data collection, data analysis, manuscript preparation or publication decision. Publisher Copyright: © 2020 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1

Y1 - 2021/1

N2 - Objective: We hypothesised that a multi-compartment magnetic resonance imaging (MRI) technique that is sensitive to fetal blood oxygenation would identify changes in placental blood volume and fetal blood oxygenation in pregnancies complicated by early-onset fetal growth restriction (FGR). Design: Case–control study. Setting: London, UK. Population: Women with uncomplicated pregnancies (estimated fetal weight [EFW] >10th centile for gestational age [GA] and normal maternal and fetal Doppler ultrasound, n = 12) or early-onset FGR (EFW <3rd centile with or without abnormal Doppler ultrasound <32 weeks GA, n = 12) were studied. Methods: All women underwent MRI examination. Using a multi-compartment MRI technique, we quantified fetal and maternal blood volume and feto-placental blood oxygenation. Main outcome measures: Disease severity was stratified according to Doppler pulsatility index and the relationship to the MRI parameters was investigated, including the influence of GA at scan. Results: The FGR group (mean GA 27 +5 weeks, range 24 +2 to 33 +6 weeks) had a significantly lower EFW compared with the control group (mean GA 29 +1 weeks; −705 g, 95% CI −353 to −1057 g). MRI-derived feto-placental oxygen saturation was higher in controls compared with FGR (75 ± 9.6% versus 56 ± 16.2%, P = 0.02, 95% CI 7.8–30.3%). Feto-placental oxygen saturation estimation correlated strongly with GA at scan in controls (r = −0.83). Conclusion: Using a novel multimodal MRI protocol we demonstrated reduced feto-placental blood oxygen saturation in pregnancies complicated by early-onset FGR. The degree of abnormality correlated with disease severity defined by ultrasound Doppler findings. Gestational age-dependent changes in oxygen saturation were also present in normal pregnancies. Tweetable abstract: MRI reveals differences in feto-placental oxygen saturation between normal and FGR pregnancy that is associated with disease severity.

AB - Objective: We hypothesised that a multi-compartment magnetic resonance imaging (MRI) technique that is sensitive to fetal blood oxygenation would identify changes in placental blood volume and fetal blood oxygenation in pregnancies complicated by early-onset fetal growth restriction (FGR). Design: Case–control study. Setting: London, UK. Population: Women with uncomplicated pregnancies (estimated fetal weight [EFW] >10th centile for gestational age [GA] and normal maternal and fetal Doppler ultrasound, n = 12) or early-onset FGR (EFW <3rd centile with or without abnormal Doppler ultrasound <32 weeks GA, n = 12) were studied. Methods: All women underwent MRI examination. Using a multi-compartment MRI technique, we quantified fetal and maternal blood volume and feto-placental blood oxygenation. Main outcome measures: Disease severity was stratified according to Doppler pulsatility index and the relationship to the MRI parameters was investigated, including the influence of GA at scan. Results: The FGR group (mean GA 27 +5 weeks, range 24 +2 to 33 +6 weeks) had a significantly lower EFW compared with the control group (mean GA 29 +1 weeks; −705 g, 95% CI −353 to −1057 g). MRI-derived feto-placental oxygen saturation was higher in controls compared with FGR (75 ± 9.6% versus 56 ± 16.2%, P = 0.02, 95% CI 7.8–30.3%). Feto-placental oxygen saturation estimation correlated strongly with GA at scan in controls (r = −0.83). Conclusion: Using a novel multimodal MRI protocol we demonstrated reduced feto-placental blood oxygen saturation in pregnancies complicated by early-onset FGR. The degree of abnormality correlated with disease severity defined by ultrasound Doppler findings. Gestational age-dependent changes in oxygen saturation were also present in normal pregnancies. Tweetable abstract: MRI reveals differences in feto-placental oxygen saturation between normal and FGR pregnancy that is associated with disease severity.

KW - Fetal growth restriction

KW - oxygenation

KW - placenta

KW - pregnancy

KW - relaxometry

UR - http://www.scopus.com/inward/record.url?scp=85088974712&partnerID=8YFLogxK

U2 - 10.1111/1471-0528.16387

DO - 10.1111/1471-0528.16387

M3 - Article

C2 - 32603546

VL - 128

SP - 337

EP - 345

JO - BJOG

JF - BJOG

SN - 1470-0328

IS - 2

ER -

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454