Major and minor salivary gland tumours

TY - JOUR

T1 - Major and minor salivary gland tumours

AU - Gatta, Gemma

AU - Guzzo, Marco

AU - Locati, Laura D.

AU - McGurk, Mark

AU - Prott, Franz Josef

PY - 2020/8

Y1 - 2020/8

N2 - Salivary glands carcinomas are very rare epithelial malignant tumors. In 2013 in Europe, 7800 new diagnoses were estimated, 8.5 % of all head and neck cancer. The last WHO classification (2017) counts more than 20 malignant histotypes, this variety as well as the rarity of some of them needs a skilled pathologist for diagnosis. Surgery remains the mainstay of management followed by radiation in high-grade and high-risk pathological features cases. The intensity modulated radiotherapy (IMRT) should be preferred over conformational radiotherapy techniques as adjuvant and exclusive treatment in advanced cases. Particle radiotherapy (i.e. protons, carbon ions) can have a role in advanced/unresectable disease since it was proved to have better results over photons in loco-regional control both in adenoid cystic carcinoma and in other histotypes. Although chemotherapy is still the most frequent treatment for metastatic patients, several new compounds (i.e. anti-angiogenic agents, tailored agents, checkpoint inhibitors) are under investigation.

AB - Salivary glands carcinomas are very rare epithelial malignant tumors. In 2013 in Europe, 7800 new diagnoses were estimated, 8.5 % of all head and neck cancer. The last WHO classification (2017) counts more than 20 malignant histotypes, this variety as well as the rarity of some of them needs a skilled pathologist for diagnosis. Surgery remains the mainstay of management followed by radiation in high-grade and high-risk pathological features cases. The intensity modulated radiotherapy (IMRT) should be preferred over conformational radiotherapy techniques as adjuvant and exclusive treatment in advanced cases. Particle radiotherapy (i.e. protons, carbon ions) can have a role in advanced/unresectable disease since it was proved to have better results over photons in loco-regional control both in adenoid cystic carcinoma and in other histotypes. Although chemotherapy is still the most frequent treatment for metastatic patients, several new compounds (i.e. anti-angiogenic agents, tailored agents, checkpoint inhibitors) are under investigation.

KW - Diagnosis

KW - Epidemiology

KW - Follow up

KW - Molecular targets

KW - Particle radiotherapy

KW - Prognosis

KW - Salivary glands carcinoma

UR - http://www.scopus.com/inward/record.url?scp=85085567266&partnerID=8YFLogxK

U2 - 10.1016/j.critrevonc.2020.102959

DO - 10.1016/j.critrevonc.2020.102959

M3 - Review article

C2 - 32485526

AN - SCOPUS:85085567266

SN - 1040-8428

VL - 152

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

M1 - 102959

ER -