Major Depressive Disorder Among HIV Infected Youth in Uganda: Incidence, Persistence and Their Predictors

TY - JOUR

T1 - Major Depressive Disorder Among HIV Infected Youth in Uganda

T2 - Incidence, Persistence and Their Predictors

AU - Kinyanda, Eugene

AU - Salisbury, Tatiana T

AU - Muyingo, Sylvia Kiwuwa

AU - Ssembajjwe, Wilber

AU - Levin, Jonathan

AU - Nakasujja, Noeline

AU - Mpango, Richard S

AU - Abbo, Catherine

AU - Seedat, Soraya

AU - Araya, Ricardo

AU - Musisi, Seggane

AU - Gadow, Kenneth D

AU - Patel, Vikram

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Incidence and persistence of major depressive disorder (MDD) in children and adolescents with HIV (CA-HIV) in Uganda is described. 1339 CA-HIV attending care were enrolled and followed up for 12 months. MDD was assessed using the DSM-5 referenced Child and Adolescent Symptom Inventory-5 (CASI-5), with a prevalence for MDD at baseline of 5% (95% CI 3.3-7.3). Kaplan-Meir method was used to estimate incidence of MDD and Cox models were fitted to investigate predictors of incident MDD. Cumulative incidence of MDD over 12 months was 7.6 per 100 person-years 95% CI (6.2-9.4) and a rate of persistent MDD of 10/105 (9.5% CI 3.9-15.1). Significant independent predictors of incident MDD were: highest educational level of CA-HIV (protective), increasing depressive scores and decreasing CD4 Nadir. These finding have implications for what should constitute components of a mental health integration model in HIV youth services and for the future development of individualised mental health care.

AB - Incidence and persistence of major depressive disorder (MDD) in children and adolescents with HIV (CA-HIV) in Uganda is described. 1339 CA-HIV attending care were enrolled and followed up for 12 months. MDD was assessed using the DSM-5 referenced Child and Adolescent Symptom Inventory-5 (CASI-5), with a prevalence for MDD at baseline of 5% (95% CI 3.3-7.3). Kaplan-Meir method was used to estimate incidence of MDD and Cox models were fitted to investigate predictors of incident MDD. Cumulative incidence of MDD over 12 months was 7.6 per 100 person-years 95% CI (6.2-9.4) and a rate of persistent MDD of 10/105 (9.5% CI 3.9-15.1). Significant independent predictors of incident MDD were: highest educational level of CA-HIV (protective), increasing depressive scores and decreasing CD4 Nadir. These finding have implications for what should constitute components of a mental health integration model in HIV youth services and for the future development of individualised mental health care.

KW - HIV infected youth

KW - Incidence

KW - Major depressive disorder

KW - Persistence

KW - Predictors

UR - http://www.scopus.com/inward/record.url?scp=85079824535&partnerID=8YFLogxK

U2 - 10.1007/s10461-020-02815-3

DO - 10.1007/s10461-020-02815-3

M3 - Article

C2 - 32078708

AN - SCOPUS:85079824535

SN - 1090-7165

VL - 24

SP - 2588

EP - 2596

JO - AIDS AND BEHAVIOR

JF - AIDS AND BEHAVIOR

IS - 9

ER -