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Management for women with subclinical hypothyroidism in pregnancy

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)22-26
JournalDrug and Therapeutics Bulletin
Issue number2
Publication statusPublished - 1 Feb 2019

King's Authors


Pregnant women do not need routine thyroid function testing for subclinical hypothyroidism (SCH). If thyroid function is tested, do not diagnose SCH if thyroid-stimulating hormone is within the normal reference range for pregnancy or <4.0mU/L. There is no consistent evidence that SCH causes harm in pregnancy or that treatment with thyroxine is beneficial. Any treatment for SCH in pregnancy is currently based on low-quality evidence. A low starting dose of thyroxine could be used (50 µg) and thyroid function tests reviewed after 4–6 weeks to ensure no harm from iatrogenic thyrotoxicosis. More data are needed to inform the management of women with SCH who are positive for thyroid antibodies.

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