Manic Symptoms in Youth: Dimensions, Latent Classes, and Associations With Parental Psychopathology

Pedro Mario Pan; Giovanni Abrahao Salum; Ary Gadelha; Tais Moriyama; Hugo Cogo-Moreira; Ana Soledade Graeff-Martins; Maria Conceicao Rosario; Guilherme Vanoni Polanczyk; Elisa Brietzke; Luis Augusto Rohde; Argyris Stringaris; Robert Goodman; Ellen Leibenluft; Rodrigo Affonseca Bressan

doi:10.1016/j.jaac.2014.03.003

Manic Symptoms in Youth: Dimensions, Latent Classes, and Associations With Parental Psychopathology

Pedro Mario Pan^*, Giovanni Abrahao Salum, Ary Gadelha, Tais Moriyama, Hugo Cogo-Moreira, Ana Soledade Graeff-Martins, Maria Conceicao Rosario, Guilherme Vanoni Polanczyk, Elisa Brietzke, Luis Augusto Rohde, Argyris Stringaris, Robert Goodman, Ellen Leibenluft, Rodrigo Affonseca Bressan

^*Corresponding author for this work

Child & Adolescent Psychiatry

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Objective: The purpose of the study was to define the latent structure of parent-reported manic symptoms and their association with functional impairment and familial risk in a community sample of Brazilian children.

Method: We screened for manic symptoms in a community sample of 2,512 children 6 to 12 years of age. Parents of children with "episodes of going abnormally high" completed a detailed mania section (n = 479; 19.1%). Confirmatory factor analysis (CFA) tested a solution with "Under-Control (UC)" and "Exuberant (EX)" dimensions, investigating the severity (threshold) and factor loading of each symptom. We also used latent class analysis (LCA) to evaluate the latent categorical structure of manic symptoms. Associations of these latent constructs with psychiatric comorbidity, psychosocial impairment, and family history of psychopathology were tested.

Results: The 2-dimensional model fit the data well. Only the UC dimension was associated with psychiatric morbidity, psychosocial impairment, and a family history of mania, depression, or suicide attempts. Both UC and EX items discriminated subjects with "episodes of going abnormally high," but EX items lay at the mild end of the severity spectrum, whereas UC items lay at the severe end. The LCA yielded a small group of children with high levels of manic symptoms and a distinct profile of psychiatric comorbidity and impairment ("high-symptom group").

Conclusion: In a large, community-based sample, we found a 2-dimensional latent structure for parent-reported manic symptoms in youth, and demonstrated familial associations between the UC dimension and affective disorders. Both UC and EX items are clinically useful, but their contributions vary with symptom severity.

Original language	English
Pages (from-to)	625-634.e2
Number of pages	12
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	53
Issue number	6
DOIs	https://doi.org/10.1016/j.jaac.2014.03.003
Publication status	Published - Jun 2014

Keywords

mania
bipolar
latent
family history
factor analysis
DIFFICULTIES QUESTIONNAIRE SDQ
BIPOLAR SPECTRUM DISORDERS
PSYCHIATRIC-DISORDERS
COMMUNITY SAMPLE
ADOLESCENTS
CHILDREN
STRENGTHS
VALIDATION
PHENOMENOLOGY
METAANALYSIS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jaac.2014.03.003

Cite this

Pan, P. M., Salum, G. A., Gadelha, A., Moriyama, T., Cogo-Moreira, H., Graeff-Martins, A. S., Rosario, M. C., Polanczyk, G. V., Brietzke, E., Rohde, L. A., Stringaris, A., Goodman, R., Leibenluft, E., & Bressan, R. A. (2014). Manic Symptoms in Youth: Dimensions, Latent Classes, and Associations With Parental Psychopathology. Journal of the American Academy of Child and Adolescent Psychiatry, 53(6), 625-634.e2. https://doi.org/10.1016/j.jaac.2014.03.003

@article{0d2cb9e8536b494f81b060edc9ded293,

title = "Manic Symptoms in Youth: Dimensions, Latent Classes, and Associations With Parental Psychopathology",

abstract = "Objective: The purpose of the study was to define the latent structure of parent-reported manic symptoms and their association with functional impairment and familial risk in a community sample of Brazilian children. Method: We screened for manic symptoms in a community sample of 2,512 children 6 to 12 years of age. Parents of children with {"}episodes of going abnormally high{"} completed a detailed mania section (n = 479; 19.1%). Confirmatory factor analysis (CFA) tested a solution with {"}Under-Control (UC){"} and {"}Exuberant (EX){"} dimensions, investigating the severity (threshold) and factor loading of each symptom. We also used latent class analysis (LCA) to evaluate the latent categorical structure of manic symptoms. Associations of these latent constructs with psychiatric comorbidity, psychosocial impairment, and family history of psychopathology were tested. Results: The 2-dimensional model fit the data well. Only the UC dimension was associated with psychiatric morbidity, psychosocial impairment, and a family history of mania, depression, or suicide attempts. Both UC and EX items discriminated subjects with {"}episodes of going abnormally high,{"} but EX items lay at the mild end of the severity spectrum, whereas UC items lay at the severe end. The LCA yielded a small group of children with high levels of manic symptoms and a distinct profile of psychiatric comorbidity and impairment ({"}high-symptom group{"}). Conclusion: In a large, community-based sample, we found a 2-dimensional latent structure for parent-reported manic symptoms in youth, and demonstrated familial associations between the UC dimension and affective disorders. Both UC and EX items are clinically useful, but their contributions vary with symptom severity.",

keywords = "mania, bipolar, latent, family history, factor analysis, DIFFICULTIES QUESTIONNAIRE SDQ, BIPOLAR SPECTRUM DISORDERS, PSYCHIATRIC-DISORDERS, COMMUNITY SAMPLE, ADOLESCENTS, CHILDREN, STRENGTHS, VALIDATION, PHENOMENOLOGY, METAANALYSIS",

author = "Pan, {Pedro Mario} and Salum, {Giovanni Abrahao} and Ary Gadelha and Tais Moriyama and Hugo Cogo-Moreira and Graeff-Martins, {Ana Soledade} and Rosario, {Maria Conceicao} and Polanczyk, {Guilherme Vanoni} and Elisa Brietzke and Rohde, {Luis Augusto} and Argyris Stringaris and Robert Goodman and Ellen Leibenluft and Bressan, {Rodrigo Affonseca}",

year = "2014",

month = jun,

doi = "10.1016/j.jaac.2014.03.003",

language = "English",

volume = "53",

pages = "625--634.e2",

journal = "Journal of the American Academy of Child and Adolescent Psychiatry",

issn = "0890-8567",

publisher = "Elsevier Limited",

number = "6",

}

Pan, PM, Salum, GA, Gadelha, A, Moriyama, T, Cogo-Moreira, H, Graeff-Martins, AS, Rosario, MC, Polanczyk, GV, Brietzke, E, Rohde, LA, Stringaris, A , Goodman, R, Leibenluft, E & Bressan, RA 2014, 'Manic Symptoms in Youth: Dimensions, Latent Classes, and Associations With Parental Psychopathology', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 53, no. 6, pp. 625-634.e2. https://doi.org/10.1016/j.jaac.2014.03.003

TY - JOUR

T1 - Manic Symptoms in Youth

T2 - Dimensions, Latent Classes, and Associations With Parental Psychopathology

AU - Pan, Pedro Mario

AU - Salum, Giovanni Abrahao

AU - Gadelha, Ary

AU - Moriyama, Tais

AU - Cogo-Moreira, Hugo

AU - Graeff-Martins, Ana Soledade

AU - Rosario, Maria Conceicao

AU - Polanczyk, Guilherme Vanoni

AU - Brietzke, Elisa

AU - Rohde, Luis Augusto

AU - Stringaris, Argyris

AU - Goodman, Robert

AU - Leibenluft, Ellen

AU - Bressan, Rodrigo Affonseca

PY - 2014/6

Y1 - 2014/6

N2 - Objective: The purpose of the study was to define the latent structure of parent-reported manic symptoms and their association with functional impairment and familial risk in a community sample of Brazilian children. Method: We screened for manic symptoms in a community sample of 2,512 children 6 to 12 years of age. Parents of children with "episodes of going abnormally high" completed a detailed mania section (n = 479; 19.1%). Confirmatory factor analysis (CFA) tested a solution with "Under-Control (UC)" and "Exuberant (EX)" dimensions, investigating the severity (threshold) and factor loading of each symptom. We also used latent class analysis (LCA) to evaluate the latent categorical structure of manic symptoms. Associations of these latent constructs with psychiatric comorbidity, psychosocial impairment, and family history of psychopathology were tested. Results: The 2-dimensional model fit the data well. Only the UC dimension was associated with psychiatric morbidity, psychosocial impairment, and a family history of mania, depression, or suicide attempts. Both UC and EX items discriminated subjects with "episodes of going abnormally high," but EX items lay at the mild end of the severity spectrum, whereas UC items lay at the severe end. The LCA yielded a small group of children with high levels of manic symptoms and a distinct profile of psychiatric comorbidity and impairment ("high-symptom group"). Conclusion: In a large, community-based sample, we found a 2-dimensional latent structure for parent-reported manic symptoms in youth, and demonstrated familial associations between the UC dimension and affective disorders. Both UC and EX items are clinically useful, but their contributions vary with symptom severity.

AB - Objective: The purpose of the study was to define the latent structure of parent-reported manic symptoms and their association with functional impairment and familial risk in a community sample of Brazilian children. Method: We screened for manic symptoms in a community sample of 2,512 children 6 to 12 years of age. Parents of children with "episodes of going abnormally high" completed a detailed mania section (n = 479; 19.1%). Confirmatory factor analysis (CFA) tested a solution with "Under-Control (UC)" and "Exuberant (EX)" dimensions, investigating the severity (threshold) and factor loading of each symptom. We also used latent class analysis (LCA) to evaluate the latent categorical structure of manic symptoms. Associations of these latent constructs with psychiatric comorbidity, psychosocial impairment, and family history of psychopathology were tested. Results: The 2-dimensional model fit the data well. Only the UC dimension was associated with psychiatric morbidity, psychosocial impairment, and a family history of mania, depression, or suicide attempts. Both UC and EX items discriminated subjects with "episodes of going abnormally high," but EX items lay at the mild end of the severity spectrum, whereas UC items lay at the severe end. The LCA yielded a small group of children with high levels of manic symptoms and a distinct profile of psychiatric comorbidity and impairment ("high-symptom group"). Conclusion: In a large, community-based sample, we found a 2-dimensional latent structure for parent-reported manic symptoms in youth, and demonstrated familial associations between the UC dimension and affective disorders. Both UC and EX items are clinically useful, but their contributions vary with symptom severity.

KW - mania

KW - bipolar

KW - latent

KW - family history

KW - factor analysis

KW - DIFFICULTIES QUESTIONNAIRE SDQ

KW - BIPOLAR SPECTRUM DISORDERS

KW - PSYCHIATRIC-DISORDERS

KW - COMMUNITY SAMPLE

KW - ADOLESCENTS

KW - CHILDREN

KW - STRENGTHS

KW - VALIDATION

KW - PHENOMENOLOGY

KW - METAANALYSIS

U2 - 10.1016/j.jaac.2014.03.003

DO - 10.1016/j.jaac.2014.03.003

M3 - Article

C2 - 24839881

SN - 0890-8567

VL - 53

SP - 625-634.e2

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

IS - 6

ER -

Manic Symptoms in Youth: Dimensions, Latent Classes, and Associations With Parental Psychopathology

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this