TY - JOUR
T1 - Mapping acute neuroinflammation in vivo with diffusion-MRI in rats given a systemic lipopolysaccharide challenge
AU - Kim, Eugene
AU - Figueiredo, Ines Carreira
AU - Simmons, Camilla
AU - Randall, Karen
AU - Gonzalez, Loreto Rojo
AU - Wood, Tobias
AU - Ranieri, Brigida
AU - Sureda-Gibert, Paula
AU - Howes, Oliver
AU - Pariante, Carmine
AU - Consortium, Nima
AU - Pasternak, Ofer
AU - Dell'Acqua, Flavio
AU - Turkheimer, Federico
AU - Cash, Diana
N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Funding Information:
This study was funded by a grant from the Wellcome Trust (Grant number: 104025/Z/14/Z).
Publisher Copyright:
© 2023 The Author(s)
PY - 2023/10
Y1 - 2023/10
N2 - It is becoming increasingly apparent that neuroinflammation plays a critical role in an array of neurological and psychiatric disorders. Recent studies have demonstrated the potential of diffusion MRI (dMRI) to characterize changes in microglial density and morphology associated with neuroinflammation, but these were conducted mostly ex vivo and/or in extreme, non-physiological animal models. Here, we build upon these studies by investigating the utility of well-established dMRI methods to detect neuroinflammation in vivo in a more clinically relevant animal model of sickness behavior. We show that diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) indicate widespread increases in diffusivity in the brains of rats given a systemic lipopolysaccharide challenge (n = 20) vs. vehicle-treated controls (n = 12). These diffusivity changes correlated with histologically measured changes in microglial morphology, confirming the sensitivity of dMRI to neuroinflammatory processes. This study marks a further step towards establishing a noninvasive indicator of neuroinflammation, which would greatly facilitate early diagnosis and treatment monitoring in various neurological and psychiatric diseases.
AB - It is becoming increasingly apparent that neuroinflammation plays a critical role in an array of neurological and psychiatric disorders. Recent studies have demonstrated the potential of diffusion MRI (dMRI) to characterize changes in microglial density and morphology associated with neuroinflammation, but these were conducted mostly ex vivo and/or in extreme, non-physiological animal models. Here, we build upon these studies by investigating the utility of well-established dMRI methods to detect neuroinflammation in vivo in a more clinically relevant animal model of sickness behavior. We show that diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) indicate widespread increases in diffusivity in the brains of rats given a systemic lipopolysaccharide challenge (n = 20) vs. vehicle-treated controls (n = 12). These diffusivity changes correlated with histologically measured changes in microglial morphology, confirming the sensitivity of dMRI to neuroinflammatory processes. This study marks a further step towards establishing a noninvasive indicator of neuroinflammation, which would greatly facilitate early diagnosis and treatment monitoring in various neurological and psychiatric diseases.
UR - http://www.scopus.com/inward/record.url?scp=85166585240&partnerID=8YFLogxK
U2 - 10.1016/j.bbi.2023.07.010
DO - 10.1016/j.bbi.2023.07.010
M3 - Article
C2 - 37482203
SN - 0889-1591
VL - 113
SP - 289
EP - 301
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
ER -