Mapping cortical surface features in treatment resistant schizophrenia with in vivo structural MRI

TY - JOUR

T1 - Mapping cortical surface features in treatment resistant schizophrenia with in vivo structural MRI

AU - Barry, Erica F.

AU - Vanes, Lucy D.

AU - Andrews, Derek S.

AU - Patel, Krisna

AU - Horne, Charlotte M.

AU - Mouchlianitis, Elias

AU - Hellyer, Peter J.

AU - Shergill, Sukhi S.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Decreases in cortical volume (CV), thickness (CT) and surface area (SA) have been reported in individuals with schizophrenia by in vivo MRI studies. However, there are few studies that examine these cortical measures as potential biomarkers of treatment resistance (TR) and treatment response (NTR) in schizophrenia. This study used structural MRI to examine differences in CV, CT, and SA in 42 adults with schizophrenia (TR = 21, NTR = 21) and 23 healthy controls (HC) to test the hypothesis that individuals with TR schizophrenia have significantly greater reductions in these cortical measures compared to individuals with NTR schizophrenia. We found that individuals with TR schizophrenia showed significant reductions in CV and CT compared to individuals with NTR schizophrenia in right frontal and precentral regions, right parietal and occipital cortex, left temporal cortex and bilateral cingulate cortex. In line with previous literature, the temporal lobe and cingulate gyrus in both patient groups showed significant reductions of all three measures when compared to healthy controls. Taken together these results suggest that regional changes in CV and CT may index mechanisms specific to TR schizophrenia and potentially identify patients with TR schizophrenia for earlier treatment.

AB - Decreases in cortical volume (CV), thickness (CT) and surface area (SA) have been reported in individuals with schizophrenia by in vivo MRI studies. However, there are few studies that examine these cortical measures as potential biomarkers of treatment resistance (TR) and treatment response (NTR) in schizophrenia. This study used structural MRI to examine differences in CV, CT, and SA in 42 adults with schizophrenia (TR = 21, NTR = 21) and 23 healthy controls (HC) to test the hypothesis that individuals with TR schizophrenia have significantly greater reductions in these cortical measures compared to individuals with NTR schizophrenia. We found that individuals with TR schizophrenia showed significant reductions in CV and CT compared to individuals with NTR schizophrenia in right frontal and precentral regions, right parietal and occipital cortex, left temporal cortex and bilateral cingulate cortex. In line with previous literature, the temporal lobe and cingulate gyrus in both patient groups showed significant reductions of all three measures when compared to healthy controls. Taken together these results suggest that regional changes in CV and CT may index mechanisms specific to TR schizophrenia and potentially identify patients with TR schizophrenia for earlier treatment.

KW - Cortical thickness

KW - Cortical volume

KW - MRI

KW - Schizophrenia

KW - Treatment resistant

UR - http://www.scopus.com/inward/record.url?scp=85062425433&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2019.02.028

DO - 10.1016/j.psychres.2019.02.028

M3 - Article

AN - SCOPUS:85062425433

SN - 0165-1781

VL - 274

SP - 335

EP - 344

JO - Psychiatry Research

JF - Psychiatry Research

ER -