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Mapping short reads to a genomic sequence with circular structure

Research output: Chapter in Book/Report/Conference proceedingConference paper

Costas S. Iliopoulos, Tewogboye A. Okanlawon, Solon P. Pissis, German Tischler

Original languageUndefined/Unknown
Title of host publicationInformation Technology and Applications in Biomedicine (ITAB), 2010 10th IEEE International Conference
Pages1-4
Number of pages4
DOIs
Publication statusPublished - 2010

King's Authors

Abstract

The constant advances in sequencing technology are turning whole-genome sequencing into a routine procedure, resulting in massive amounts of data that need to be processed. Tens of gigabytes of data in the form of short reads need to be mapped back to reference sequences, a few gigabases long. These high-throughput (or next-generation) technologies allow researchers to characterise a bacterial genome during a single experiment and at a moderate cost. In this paper, as most of the bacteria have a single circular chromosome, we present a simple, yet efficient, accurate and consistent algorithm, to solve the practical problem of matching millions of short reads to a genomic sequence with circular structure.

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