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Mapping the MHC class I spliced immunopeptidome of cancer cells

Research output: Contribution to journalArticle

Julaine Liepe, John Sidney, Felix Km Lorenz, Alessandro Sette, Michele Mishto

Original languageEnglish
Pages (from-to)62-76
Number of pages15
JournalCancer immunology research
Volume7
Issue number1
Early online date13 Nov 2018
DOIs
Publication statusPublished - Jan 2019

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Abstract

Anti-cancer immunotherapies demand optimal epitope targets, which could include proteasome-generated spliced peptides if tumor cells were to present them. Here, we show that spliced peptides are widely presented by MHC class I molecules of colon and breast carcinoma cell lines. The peptides derive from hot spots within antigens and enlarge the antigen coverage. Spliced peptides also represent a large number of antigens that would otherwise be neglected by patrolling T cells. These antigens tend to be long, hydrophobic, and basic. Thus, spliced peptides can be a key to identifying targets in an enlarged pool of antigens associated with cancer.

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