King's College London

Research portal

Mapping the MHC class I spliced immunopeptidome of cancer cells

Research output: Contribution to journalArticle

Julaine Liepe, John Sidney, Felix Km Lorenz, Alessandro Sette, Michele Mishto

Original languageEnglish
Pages (from-to)62-76
Number of pages15
JournalCancer immunology research
Issue number1
Early online date13 Nov 2018
Publication statusPublished - Jan 2019


King's Authors


Anti-cancer immunotherapies demand optimal epitope targets, which could include proteasome-generated spliced peptides if tumor cells were to present them. Here, we show that spliced peptides are widely presented by MHC class I molecules of colon and breast carcinoma cell lines. The peptides derive from hot spots within antigens and enlarge the antigen coverage. Spliced peptides also represent a large number of antigens that would otherwise be neglected by patrolling T cells. These antigens tend to be long, hydrophobic, and basic. Thus, spliced peptides can be a key to identifying targets in an enlarged pool of antigens associated with cancer.

Download statistics

No data available

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454