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Massive parallel sequencing in forensics: advantages, issues, technicalities, and prospects

Research output: Contribution to journalReview article

David Ballard, Jakub Winkler-Galicki, Joanna Wesoły

Original languageEnglish
Pages (from-to)1291-1303
Number of pages13
JournalInternational Journal of Legal Medicine
Volume134
Issue number4
DOIs
Published1 Jul 2020

King's Authors

Abstract

In the last decade, next-generation sequencing (NGS) technology, alternatively massive parallel sequencing (MPS), was applied to all fields of biological research. Its introduction to the field of forensics was slower, mainly due to lack of accredited sequencers, kits, and relatively higher sequencing error rates as compared with standardized Sanger sequencing. Currently, a majority of the problematic issues have been solved, which is proven by the body of reports in the literature. Here, we discuss the utility of NGS sequencing in forensics, emphasizing the advantages, issues, the technical aspects of the experiments, commercial solutions, and the potentially interesting applications of MPS.

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