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Master control: transcriptional regulation of mammalian Myod

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)211-226
Number of pages16
JournalJournal of Muscle Research and Cell Motility
Volume40
Issue number2
Early online date12 Jul 2019
DOIs
Publication statusE-pub ahead of print - 12 Jul 2019

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Abstract

MYOD is a master regulator of the skeletal myogenic program. But what regulates expression of Myod? More than 20 years ago, studies established that Myod expression is largely controlled by just two enhancer regions located within a region 24 kb upstream of the transcription start site in mammals, which regulate Myod expression in the embryo, fetus and adult. Despite this apparently simple arrangement, Myod regulation is complex, with different combinations of transcription factors acting on these enhancers in different muscle progenitor cells and phases of differentiation. A range of epigenetic modifications in the Myod upstream region also play a part in activating and repressing Myod expression during development and regeneration. Here the evidence for this binding at Myod control regions is summarized, giving an overview of our current understanding of Myod expression regulation in mammals.

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