Abstract
MYOD is a master regulator of the skeletal myogenic program. But what regulates expression of Myod? More than 20 years ago, studies established that Myod expression is largely controlled by just two enhancer regions located within a region 24 kb upstream of the transcription start site in mammals, which regulate Myod expression in the embryo, fetus and adult. Despite this apparently simple arrangement, Myod regulation is complex, with different combinations of transcription factors acting on these enhancers in different muscle progenitor cells and phases of differentiation. A range of epigenetic modifications in the Myod upstream region also play a part in activating and repressing Myod expression during development and regeneration. Here the evidence for this binding at Myod control regions is summarized, giving an overview of our current understanding of Myod expression regulation in mammals.
| Original language | English |
|---|---|
| Pages (from-to) | 211-226 |
| Number of pages | 16 |
| Journal | Journal of Muscle Research and Cell Motility |
| Volume | 40 |
| Issue number | 2 |
| Early online date | 12 Jul 2019 |
| DOIs | |
| Publication status | E-pub ahead of print - 12 Jul 2019 |
Keywords
- Epigenetic regulation
- Mammalian embryo
- Myod
- Myogenesis
- Transcription factor