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Maternal Cardiac Assessment at 35 to 37 Weeks Improves Prediction of Development of Preeclampsia

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Maternal Cardiac Assessment at 35 to 37 Weeks Improves Prediction of Development of Preeclampsia. / Garcia-Gonzalez, Coral; Georgiopoulos, Georgios; Azim, Samira Abdel; Macaya, Fernando; Kametas, Nikos; Nihoyannopoulos, Petros; Nicolaides, Kypros H.; Charakida, Marietta.

In: Hypertension, 01.01.2020, p. 514-522.

Research output: Contribution to journalArticle

Harvard

Garcia-Gonzalez, C, Georgiopoulos, G, Azim, SA, Macaya, F, Kametas, N, Nihoyannopoulos, P, Nicolaides, KH & Charakida, M 2020, 'Maternal Cardiac Assessment at 35 to 37 Weeks Improves Prediction of Development of Preeclampsia', Hypertension, pp. 514-522. https://doi.org/10.1161/HYPERTENSIONAHA.120.14643

APA

Garcia-Gonzalez, C., Georgiopoulos, G., Azim, S. A., Macaya, F., Kametas, N., Nihoyannopoulos, P., Nicolaides, K. H., & Charakida, M. (Accepted/In press). Maternal Cardiac Assessment at 35 to 37 Weeks Improves Prediction of Development of Preeclampsia. Hypertension, 514-522. https://doi.org/10.1161/HYPERTENSIONAHA.120.14643

Vancouver

Garcia-Gonzalez C, Georgiopoulos G, Azim SA, Macaya F, Kametas N, Nihoyannopoulos P et al. Maternal Cardiac Assessment at 35 to 37 Weeks Improves Prediction of Development of Preeclampsia. Hypertension. 2020 Jan 1;514-522. https://doi.org/10.1161/HYPERTENSIONAHA.120.14643

Author

Garcia-Gonzalez, Coral ; Georgiopoulos, Georgios ; Azim, Samira Abdel ; Macaya, Fernando ; Kametas, Nikos ; Nihoyannopoulos, Petros ; Nicolaides, Kypros H. ; Charakida, Marietta. / Maternal Cardiac Assessment at 35 to 37 Weeks Improves Prediction of Development of Preeclampsia. In: Hypertension. 2020 ; pp. 514-522.

Bibtex Download

@article{48728b0c676c4a7a8939d57604c35356,
title = "Maternal Cardiac Assessment at 35 to 37 Weeks Improves Prediction of Development of Preeclampsia",
abstract = "Preeclampsia at term accounts for half of maternal deaths from hypertensive disorders. We aimed to assess differences in maternal cardiac indices at 35+0to 36+6weeks' gestation between women who subsequently developed preeclampsia at term compared with those with uncomplicated pregnancy and to evaluate whether cardiac indices offer incremental prognostic value to the available screening algorithm for preeclampsia. We recruited 1602 women with singleton pregnancies who attended for a routine hospital visit at 35+0to 36+6weeks' gestation between April and November 2018. We recorded maternal characteristics and preeclampsia-risk-score derived from a competing risks model and measured cardiac indices. Preeclampsia developed in 3.12% (50/1602) of participants. Women with preeclampsia, compared with those without, had increased mean arterial pressure (97.6, SD, 5.53 versus 87.9, SD, 6.82 mm Hg), systemic vascular resistance (1500, interquartile range, 1393-1831 versus 1400, interquartile range, 1202-1630 PRU) and preeclampsia-risk-score (23.4, interquartile range, 9.13-40 versus 0.9, interquartile range, 0.32-3.25). Multivariable analysis demonstrated independent association between the incidence of preeclampsia and E/e′ (hazard ratio, 1.19/unit [95% CI, 1.03-1.37]; P=0.018) as well as left ventricular mass indexed for body surface area (hazard ratio, 1.03/[g·m2] [95% CI, 1.003-1.051]; P=0.029). Women with E/e′ ≥7.3 and left ventricular mass indexed for body surface area ≥63.2 g/m2had an increased risk for developing preeclampsia, despite low preeclampsia-risk-score <5% (hazard ratio, 20.1 [95% CI, 10.5-38.7], P<0.001). Increased left ventricular mass and E/e′ offer incremental information to available scoring systems and better stratify women at risk of developing preeclampsia at term.",
keywords = "diastolic function, morbidity, mortality, preeclampsia, pregnancy",
author = "Coral Garcia-Gonzalez and Georgios Georgiopoulos and Azim, {Samira Abdel} and Fernando Macaya and Nikos Kametas and Petros Nihoyannopoulos and Nicolaides, {Kypros H.} and Marietta Charakida",
year = "2020",
month = jan,
day = "1",
doi = "10.1161/HYPERTENSIONAHA.120.14643",
language = "English",
pages = "514--522",
journal = "Hypertension (Dallas, Tex. : 1979)",
issn = "0194-911X",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Maternal Cardiac Assessment at 35 to 37 Weeks Improves Prediction of Development of Preeclampsia

AU - Garcia-Gonzalez, Coral

AU - Georgiopoulos, Georgios

AU - Azim, Samira Abdel

AU - Macaya, Fernando

AU - Kametas, Nikos

AU - Nihoyannopoulos, Petros

AU - Nicolaides, Kypros H.

AU - Charakida, Marietta

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Preeclampsia at term accounts for half of maternal deaths from hypertensive disorders. We aimed to assess differences in maternal cardiac indices at 35+0to 36+6weeks' gestation between women who subsequently developed preeclampsia at term compared with those with uncomplicated pregnancy and to evaluate whether cardiac indices offer incremental prognostic value to the available screening algorithm for preeclampsia. We recruited 1602 women with singleton pregnancies who attended for a routine hospital visit at 35+0to 36+6weeks' gestation between April and November 2018. We recorded maternal characteristics and preeclampsia-risk-score derived from a competing risks model and measured cardiac indices. Preeclampsia developed in 3.12% (50/1602) of participants. Women with preeclampsia, compared with those without, had increased mean arterial pressure (97.6, SD, 5.53 versus 87.9, SD, 6.82 mm Hg), systemic vascular resistance (1500, interquartile range, 1393-1831 versus 1400, interquartile range, 1202-1630 PRU) and preeclampsia-risk-score (23.4, interquartile range, 9.13-40 versus 0.9, interquartile range, 0.32-3.25). Multivariable analysis demonstrated independent association between the incidence of preeclampsia and E/e′ (hazard ratio, 1.19/unit [95% CI, 1.03-1.37]; P=0.018) as well as left ventricular mass indexed for body surface area (hazard ratio, 1.03/[g·m2] [95% CI, 1.003-1.051]; P=0.029). Women with E/e′ ≥7.3 and left ventricular mass indexed for body surface area ≥63.2 g/m2had an increased risk for developing preeclampsia, despite low preeclampsia-risk-score <5% (hazard ratio, 20.1 [95% CI, 10.5-38.7], P<0.001). Increased left ventricular mass and E/e′ offer incremental information to available scoring systems and better stratify women at risk of developing preeclampsia at term.

AB - Preeclampsia at term accounts for half of maternal deaths from hypertensive disorders. We aimed to assess differences in maternal cardiac indices at 35+0to 36+6weeks' gestation between women who subsequently developed preeclampsia at term compared with those with uncomplicated pregnancy and to evaluate whether cardiac indices offer incremental prognostic value to the available screening algorithm for preeclampsia. We recruited 1602 women with singleton pregnancies who attended for a routine hospital visit at 35+0to 36+6weeks' gestation between April and November 2018. We recorded maternal characteristics and preeclampsia-risk-score derived from a competing risks model and measured cardiac indices. Preeclampsia developed in 3.12% (50/1602) of participants. Women with preeclampsia, compared with those without, had increased mean arterial pressure (97.6, SD, 5.53 versus 87.9, SD, 6.82 mm Hg), systemic vascular resistance (1500, interquartile range, 1393-1831 versus 1400, interquartile range, 1202-1630 PRU) and preeclampsia-risk-score (23.4, interquartile range, 9.13-40 versus 0.9, interquartile range, 0.32-3.25). Multivariable analysis demonstrated independent association between the incidence of preeclampsia and E/e′ (hazard ratio, 1.19/unit [95% CI, 1.03-1.37]; P=0.018) as well as left ventricular mass indexed for body surface area (hazard ratio, 1.03/[g·m2] [95% CI, 1.003-1.051]; P=0.029). Women with E/e′ ≥7.3 and left ventricular mass indexed for body surface area ≥63.2 g/m2had an increased risk for developing preeclampsia, despite low preeclampsia-risk-score <5% (hazard ratio, 20.1 [95% CI, 10.5-38.7], P<0.001). Increased left ventricular mass and E/e′ offer incremental information to available scoring systems and better stratify women at risk of developing preeclampsia at term.

KW - diastolic function

KW - morbidity

KW - mortality

KW - preeclampsia

KW - pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85087900779&partnerID=8YFLogxK

U2 - 10.1161/HYPERTENSIONAHA.120.14643

DO - 10.1161/HYPERTENSIONAHA.120.14643

M3 - Article

C2 - 32564692

AN - SCOPUS:85087900779

SP - 514

EP - 522

JO - Hypertension (Dallas, Tex. : 1979)

JF - Hypertension (Dallas, Tex. : 1979)

SN - 0194-911X

ER -

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