Maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring: A population-based birth cohort study

Syudo Yamasaki; Shuntaro Ando; Marcus Richards; Stephani L. Hatch; Shinsuke Koike; Shinya Fujikawa; Sho Kanata; Kaori Endo; Yuko Morimoto; Makoto Arai; Haruo Okado; Satoshi Usami; Toshiaki A. Furukawa; Mariko Hiraiwa-Hasegawa; Kiyoto Kasai; Atsushi Nishida

doi:10.1016/j.schres.2018.12.016

Maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring: A population-based birth cohort study

Syudo Yamasaki, Shuntaro Ando, Marcus Richards, Stephani L. Hatch, Shinsuke Koike, Shinya Fujikawa, Sho Kanata, Kaori Endo, Yuko Morimoto, Makoto Arai, Haruo Okado, Satoshi Usami, Toshiaki A. Furukawa, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Epidemiological studies have suggested that maternal diabetes in pregnancy increases the risk of schizophrenia in offspring. A recent cohort study observed that maternal diabetes in early pregnancy is also associated with psychotic experiences in the general adolescent population. However, it remains unclear whether maternal diabetes in early pregnancy is specifically associated with psychotic experiences, or is generally associated with broader mental health problems, including depressive symptoms in adolescence. The present study investigated the longitudinal associations between maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring. Our data were derived from the Tokyo Early Adolescence Survey, a population-based survey of early adolescents (N = 4478) and their primary caregivers. Diabetes in early pregnancy was determined by records in the mother's Maternal and Child Health Handbook, documented during the pregnancy. Psychotic experiences and depressive symptoms were established through self-report by the offspring at 10 years of age. Diabetes in early pregnancy was associated with an increased risk of hallucination in the offspring (auditory hallucination [odds ratio {OR} 4.33, 95% confidence interval {CI} 1.12–16.75]; visual hallucination [OR 6.58, 95% CI 1.69–25.66]), even after adjusting for depressive symptoms and other covariates. However, the association between maternal diabetes and delusional thoughts was not significant and diabetes in early pregnancy was not associated with adolescent depressive symptoms. Our investigation suggests that maternal diabetes in early pregnancy may specifically affect the risk of hallucinatory experiences in adolescent offspring.

Original language	English
Journal	Schizophrenia Research
Early online date	26 Dec 2018
DOIs	https://doi.org/10.1016/j.schres.2018.12.016
Publication status	E-pub ahead of print - 26 Dec 2018

Keywords

Adolescence
Depression
Diabetes
Hallucination
Perinatal

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2018.12.016

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Yamasaki, S., Ando, S., Richards, M., Hatch, S. L., Koike, S., Fujikawa, S., Kanata, S., Endo, K., Morimoto, Y., Arai, M., Okado, H., Usami, S., Furukawa, T. A., Hiraiwa-Hasegawa, M., Kasai, K., & Nishida, A. (2018). Maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring: A population-based birth cohort study. Schizophrenia Research. Advance online publication. https://doi.org/10.1016/j.schres.2018.12.016

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title = "Maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring: A population-based birth cohort study",

abstract = "Epidemiological studies have suggested that maternal diabetes in pregnancy increases the risk of schizophrenia in offspring. A recent cohort study observed that maternal diabetes in early pregnancy is also associated with psychotic experiences in the general adolescent population. However, it remains unclear whether maternal diabetes in early pregnancy is specifically associated with psychotic experiences, or is generally associated with broader mental health problems, including depressive symptoms in adolescence. The present study investigated the longitudinal associations between maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring. Our data were derived from the Tokyo Early Adolescence Survey, a population-based survey of early adolescents (N = 4478) and their primary caregivers. Diabetes in early pregnancy was determined by records in the mother's Maternal and Child Health Handbook, documented during the pregnancy. Psychotic experiences and depressive symptoms were established through self-report by the offspring at 10 years of age. Diabetes in early pregnancy was associated with an increased risk of hallucination in the offspring (auditory hallucination [odds ratio {OR} 4.33, 95% confidence interval {CI} 1.12–16.75]; visual hallucination [OR 6.58, 95% CI 1.69–25.66]), even after adjusting for depressive symptoms and other covariates. However, the association between maternal diabetes and delusional thoughts was not significant and diabetes in early pregnancy was not associated with adolescent depressive symptoms. Our investigation suggests that maternal diabetes in early pregnancy may specifically affect the risk of hallucinatory experiences in adolescent offspring.",

keywords = "Adolescence, Depression, Diabetes, Hallucination, Perinatal",

author = "Syudo Yamasaki and Shuntaro Ando and Marcus Richards and Hatch, {Stephani L.} and Shinsuke Koike and Shinya Fujikawa and Sho Kanata and Kaori Endo and Yuko Morimoto and Makoto Arai and Haruo Okado and Satoshi Usami and Furukawa, {Toshiaki A.} and Mariko Hiraiwa-Hasegawa and Kiyoto Kasai and Atsushi Nishida",

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Yamasaki, S, Ando, S, Richards, M, Hatch, SL, Koike, S, Fujikawa, S, Kanata, S, Endo, K, Morimoto, Y, Arai, M, Okado, H, Usami, S, Furukawa, TA, Hiraiwa-Hasegawa, M, Kasai, K & Nishida, A 2018, 'Maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring: A population-based birth cohort study', Schizophrenia Research. https://doi.org/10.1016/j.schres.2018.12.016

TY - JOUR

T1 - Maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring

T2 - A population-based birth cohort study

AU - Yamasaki, Syudo

AU - Ando, Shuntaro

AU - Richards, Marcus

AU - Hatch, Stephani L.

AU - Koike, Shinsuke

AU - Fujikawa, Shinya

AU - Kanata, Sho

AU - Endo, Kaori

AU - Morimoto, Yuko

AU - Arai, Makoto

AU - Okado, Haruo

AU - Usami, Satoshi

AU - Furukawa, Toshiaki A.

AU - Hiraiwa-Hasegawa, Mariko

AU - Kasai, Kiyoto

AU - Nishida, Atsushi

PY - 2018/12/26

Y1 - 2018/12/26

N2 - Epidemiological studies have suggested that maternal diabetes in pregnancy increases the risk of schizophrenia in offspring. A recent cohort study observed that maternal diabetes in early pregnancy is also associated with psychotic experiences in the general adolescent population. However, it remains unclear whether maternal diabetes in early pregnancy is specifically associated with psychotic experiences, or is generally associated with broader mental health problems, including depressive symptoms in adolescence. The present study investigated the longitudinal associations between maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring. Our data were derived from the Tokyo Early Adolescence Survey, a population-based survey of early adolescents (N = 4478) and their primary caregivers. Diabetes in early pregnancy was determined by records in the mother's Maternal and Child Health Handbook, documented during the pregnancy. Psychotic experiences and depressive symptoms were established through self-report by the offspring at 10 years of age. Diabetes in early pregnancy was associated with an increased risk of hallucination in the offspring (auditory hallucination [odds ratio {OR} 4.33, 95% confidence interval {CI} 1.12–16.75]; visual hallucination [OR 6.58, 95% CI 1.69–25.66]), even after adjusting for depressive symptoms and other covariates. However, the association between maternal diabetes and delusional thoughts was not significant and diabetes in early pregnancy was not associated with adolescent depressive symptoms. Our investigation suggests that maternal diabetes in early pregnancy may specifically affect the risk of hallucinatory experiences in adolescent offspring.

AB - Epidemiological studies have suggested that maternal diabetes in pregnancy increases the risk of schizophrenia in offspring. A recent cohort study observed that maternal diabetes in early pregnancy is also associated with psychotic experiences in the general adolescent population. However, it remains unclear whether maternal diabetes in early pregnancy is specifically associated with psychotic experiences, or is generally associated with broader mental health problems, including depressive symptoms in adolescence. The present study investigated the longitudinal associations between maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring. Our data were derived from the Tokyo Early Adolescence Survey, a population-based survey of early adolescents (N = 4478) and their primary caregivers. Diabetes in early pregnancy was determined by records in the mother's Maternal and Child Health Handbook, documented during the pregnancy. Psychotic experiences and depressive symptoms were established through self-report by the offspring at 10 years of age. Diabetes in early pregnancy was associated with an increased risk of hallucination in the offspring (auditory hallucination [odds ratio {OR} 4.33, 95% confidence interval {CI} 1.12–16.75]; visual hallucination [OR 6.58, 95% CI 1.69–25.66]), even after adjusting for depressive symptoms and other covariates. However, the association between maternal diabetes and delusional thoughts was not significant and diabetes in early pregnancy was not associated with adolescent depressive symptoms. Our investigation suggests that maternal diabetes in early pregnancy may specifically affect the risk of hallucinatory experiences in adolescent offspring.

KW - Adolescence

KW - Depression

KW - Diabetes

KW - Hallucination

KW - Perinatal

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U2 - 10.1016/j.schres.2018.12.016

DO - 10.1016/j.schres.2018.12.016

M3 - Article

AN - SCOPUS:85059046665

SN - 0920-9964

JO - Schizophrenia Research

JF - Schizophrenia Research

ER -

Maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring: A population-based birth cohort study

Abstract

Keywords

UN SDGs

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