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Maternal high triglyceride levels during early pregnancy and risk of preterm delivery: A retrospective cohort study

Research output: Contribution to journalArticle

Xian Hua Lin, Dan Dan Wu, Cheng Li, Yi Jing Xu, Ling Gao, Geffen Lass, Jian Zhang, Shen Tian, Deyana Ivanova, Lin Tang, Lei Chen, Rong Ding, Xi Mei Liu, Mi Han, Jian Xia Fan, Xiao Feng Li, Jian Zhong Sheng, Kevin T. O'Byrne, He Feng Huang

Original languageEnglish
Pages (from-to)1249-1258
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Issue number4
Publication statusPublished - 1 Apr 2019

King's Authors


Context: Maternal obesity increases the risk of preterm delivery. Obesity is known to be associated with altered lipid metabolism. Objective: To investigate the associations between high maternal triglyceride (mTG) levels during early pregnancy and risks of preterm delivery stratified by early pregnancy body mass index (BMI). Design: Retrospective cohort study. Setting: University-based maternity center. Patients: 49,612 women with singleton pregnancy who underwent fasting serum lipid screening during early pregnancy. Main Outcome Measures: Risk of preterm delivery (total, <37 weeks; early, 28 to 33 weeks; and late, 34 to 36 weeks). Results: Among women enrolled, 2494 had a preterm delivery, including 438 early preterm and 2056 late preterm delivery. High mTG (>90th percentile, 2.04 mM) was associated with shortened gestation. Risks of total, early, and late preterm deliveries increased with mTG levels, and the high mTG-related risk was highest for early preterm delivery [adjusted odds ratio (AOR) 1.72; 95% CI, 1.30 to 2.29]. After stratification by BMI, high mTG was associated with risk of preterm delivery in both overweight or obese (OWO) women (AOR 1.32; 95% CI, 1.02 to 1.70) and women with normal BMI (AOR 1.36; 95% CI, 1.16 to 1.59). In additional sensitivity analyses, we found that high mTG was related to higher risks of preterm delivery amongOWOwomen and women with normal BMI (AOR, 1.54; 95% CI, 1.07 to 2.22 and 1.62, 1.34 to 1.96, respectively), especially early preterm delivery (AOR 2.47; 95% CI, 1.19 to 5.10, and AOR 2.50; 95% CI, 1.65 to 3.78, respectively). Conclusions: High mTG level during early pregnancy increased the risks of preterm delivery not only in OWO women but also in women with normal BMI.

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