Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications

TY - JOUR

T1 - Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications

AU - Leemaqz, Shalem Y.

AU - Dekker, Gustaaf A.

AU - McCowan, Lesley M.

AU - Kenny, Louise C.

AU - Myers, Jenny E.

AU - Simpson, Nigel A B

AU - Poston, Lucilla

AU - Roberts, Claire T.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Widespread legalisation of marijuana raises safety concerns for its use in pregnancy. This study investigated the association of marijuana use prior to and during pregnancy with pregnancy outcomes in a prospective cohort of 5588 nulliparous women from the international SCOPE study. Women were assessed at 15 ± 1 and 20 ± 1 weeks' gestation. Cases [278 Preeclampsia, 470 gestational hypertension, 633 small-for-gestational-age, 236 spontaneous preterm births (SPTB), 143 gestational diabetes] were compared separately with 4114 non-cases. Although the numbers are small, continued maternal marijuana use at 20 weeks' gestation was associated with SPTB independent of cigarette smoking status [adj OR 2.28 (95% CI:1.45-3.59)] and socioeconomic index (SEI) [adj OR 2.17 (95% CI:1.41-3.34)]. When adjusted for maternal age, cigarette smoking, alcohol and SEI, continued maternal marijuana use at 20 weeks' gestation had a greater effect size [adj OR 5.44 (95% CI 2.44-12.11)]. Our data indicate that increasing use of marijuana among young women of reproductive age is a major public health concern.

AB - Widespread legalisation of marijuana raises safety concerns for its use in pregnancy. This study investigated the association of marijuana use prior to and during pregnancy with pregnancy outcomes in a prospective cohort of 5588 nulliparous women from the international SCOPE study. Women were assessed at 15 ± 1 and 20 ± 1 weeks' gestation. Cases [278 Preeclampsia, 470 gestational hypertension, 633 small-for-gestational-age, 236 spontaneous preterm births (SPTB), 143 gestational diabetes] were compared separately with 4114 non-cases. Although the numbers are small, continued maternal marijuana use at 20 weeks' gestation was associated with SPTB independent of cigarette smoking status [adj OR 2.28 (95% CI:1.45-3.59)] and socioeconomic index (SEI) [adj OR 2.17 (95% CI:1.41-3.34)]. When adjusted for maternal age, cigarette smoking, alcohol and SEI, continued maternal marijuana use at 20 weeks' gestation had a greater effect size [adj OR 5.44 (95% CI 2.44-12.11)]. Our data indicate that increasing use of marijuana among young women of reproductive age is a major public health concern.

KW - BMI

KW - Marijuana

KW - Pregnancy outcome

KW - Smoking

KW - Spontaneous preterm birth

UR - http://www.scopus.com/inward/record.url?scp=84964812715&partnerID=8YFLogxK

U2 - 10.1016/j.reprotox.2016.04.021

DO - 10.1016/j.reprotox.2016.04.021

M3 - Article

AN - SCOPUS:84964812715

SN - 0890-6238

VL - 62

SP - 77

EP - 86

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -